Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2634714..2635228 Replicon chromosome
Accession NZ_CP062421
Organism Staphylococcus aureus strain NAS_AN_003

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF693_RS12985 Protein ID WP_000581792.1
Coordinates 2635019..2635228 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF693_RS12980 Protein ID WP_000138932.1
Coordinates 2634714..2635007 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF693_RS12960 (2630078) 2630078..2630719 + 642 WP_000483156.1 thiamine phosphate synthase -
IF693_RS12965 (2630805) 2630805..2631677 + 873 WP_000725800.1 membrane protein insertase YidC -
IF693_RS12970 (2632389) 2632389..2633036 - 648 WP_001187630.1 HD domain-containing protein -
IF693_RS12975 (2633064) 2633064..2634548 - 1485 WP_000571549.1 cardiolipin synthase -
IF693_RS12980 (2634714) 2634714..2635007 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF693_RS12985 (2635019) 2635019..2635228 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF693_RS12990 (2635356) 2635356..2635493 + 138 WP_000828354.1 Lmo0850 family protein -
IF693_RS12995 (2635757) 2635757..2636959 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF693_RS13000 (2637277) 2637277..2638347 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF693_RS13005 (2638362) 2638362..2639720 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T175242 WP_000581792.1 NZ_CP062421:2635019-2635228 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T175242 NZ_CP081844:2946781-2947035 [Caenibius sp. WL]
ATGAACAGCAAGCAGTCCAAGACGCTCAAAGCCATCTTCTCCGATCCGGTTTCGGGAACGATCAAATGGGCGTCTATTGA
AAGTCTGTTCGTCGCGGTCGGTTGCGAAATAATCGAGGGCAAGGGATCGCATGTCCAAGCCCACAAGGATGGCGTGATAG
GTTATTTCGTCCGCCCCCATCCGAACAAGGAGGCCAAGCGCTACCAAATTCGGGATGTGAGGGAATTTCTAGCGAAGATT
GGAGTTGAGCCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT175242 WP_000138932.1 NZ_CP062421:2634714-2635007 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT175242 NZ_CP081844:2947032-2947364 [Caenibius sp. WL]
ATGAACGTCATGAGTCACAAAGGTTACAGCGCCCGCATCGAATATGATGATGACGATGGCATTTTTTTCGGCAGGCTTGC
CGGTATCAATGATGTGGTCGGCTTTCATGCCGATAGCGTCGAAGAACTGCGCGCCGCCTTTCACGAGGCCGTGGACGATT
ACATCGAAGCATGCGCGAAGATCGGGAAAGACCCTCAGAAGCCCTATTCCGGCAAGATGATGTTTCGCGTGAGCCCCGAG
CTACATCGCCGGGCGGCCATCGCGGCTGAACTGGCGGGCAAGAGCCTTAACCAGTGGGCGGAGGAAGCCCTGCATGAGGC
GCTTCCTCACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References