Detailed information of TA system TA175233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1148005..1148482
• Replicon: chromosome
• Accession: NZ_CP062421
• Organism: Staphylococcus aureus strain NAS_AN_003

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF693_RS05750
• Protein ID: WP_000052076.1
• Coordinates: 1148294..1148482 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF693_RS05745
• Protein ID: WP_001059690.1
• Coordinates: 1148005..1148265 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF693_RS05710 (1143398)	1143398..1144114	-	717	WP_000150019.1	type I 3-dehydroquinate dehydratase	-
IF693_RS05715 (1144262)	1144262..1144684	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF693_RS05720 (1145083)	1145083..1145577	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF693_RS05725 (1145732)	1145732..1146349	+	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
IF693_RS05730 (1146422)	1146422..1147003	-	582	WP_001140697.1	histidine phosphatase family protein	-
IF693_RS05735 (1147228)	1147228..1147464	+	237	WP_000368687.1	hypothetical protein	-
IF693_RS05740 (1147461)	1147461..1147664	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF693_RS05745 (1148005)	1148005..1148265	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF693_RS05750 (1148294)	1148294..1148482	+	189	WP_000052076.1	hypothetical protein	Toxin
IF693_RS05755 (1148670)	1148670..1149239	+	570	WP_001106652.1	lipoprotein N-acylation protein LnsA	-
IF693_RS05760 (1149327)	1149327..1149611	+	285	WP_001004394.1	hypothetical protein	-
IF693_RS05765 (1149673)	1149673..1149898	+	226	Protein_1110	hypothetical protein	-
IF693_RS05770 (1150393)	1150393..1150593	-	201	WP_001059082.1	cold-shock protein	-
IF693_RS05775 (1150950)	1150950..1151636	-	687	WP_001566557.1	thermonuclease family protein	-
IF693_RS05780 (1151977)	1151977..1152447	-	471	WP_000824472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-79)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T175233 WP_000052076.1 NZ_CP062421:1148294-1148482 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T175233 NZ_CP081827:c4768156-4767917 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGCGTTTGATCCGCGTGCCTGGCGCGAATGGCAGAAGCTTGGCGAGACGATCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGGTTGTGCAGAATCCGCGAATTGCATCGGCCAGTCTGAGTGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGGGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT175233 WP_001059690.1 NZ_CP062421:1148005-1148265 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT175233 NZ_CP081827:c4768388-4768146 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTGCGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCAGTGAAAAGTATGACTATCAGCGATA
GCGAAGCGGCATTATTACGCACCGTCCGCGAGCGGCTGGAAAACCCGCAGCCGGAGGTGAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56