Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 121140..121916 Replicon chromosome
Accession NZ_CP062421
Organism Staphylococcus aureus strain NAS_AN_003

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag IF693_RS00780 Protein ID WP_000031108.1
Coordinates 121764..121916 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag IF693_RS00775 Protein ID WP_001251224.1
Coordinates 121140..121739 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF693_RS00755 (117056) 117056..118513 + 1458 WP_000649908.1 ABC transporter permease subunit -
IF693_RS00760 (118506) 118506..119228 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
IF693_RS00765 (119379) 119379..120506 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
IF693_RS00770 (120511) 120511..120981 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
IF693_RS00775 (121140) 121140..121739 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
IF693_RS00780 (121764) 121764..121916 + 153 WP_000031108.1 SAS053 family protein Toxin
IF693_RS00785 (122464) 122464..122859 + 396 WP_000901023.1 hypothetical protein -
IF693_RS00790 (123055) 123055..124440 + 1386 WP_000116229.1 class II fumarate hydratase -
IF693_RS00795 (124892) 124892..125713 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T175230 WP_000031108.1 NZ_CP062421:121764-121916 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T175230 NZ_CP081827:1930343-1930445 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT175230 WP_001251224.1 NZ_CP062421:121140-121739 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT175230 NZ_CP081827:c1930449-1930302 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References