Detailed information of TA system TA175225

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2703069..2703580
• Replicon: chromosome
• Accession: NZ_CP062420
• Organism: Staphylococcus aureus strain NAS_AN_016

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: IF696_RS13400
• Protein ID: WP_001103943.1
• Coordinates: 2703281..2703580 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: IF696_RS13395
• Protein ID: WP_001058486.1
• Coordinates: 2703069..2703278 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF696_RS13360 (2698368)	2698368..2698652	+	285	WP_000917289.1	co-chaperone GroES	-
IF696_RS13365 (2698728)	2698728..2700344	+	1617	WP_000240645.1	chaperonin GroEL	-
IF696_RS13370 (2700413)	2700413..2701585	-	1173	WP_000179352.1	tyrosine-type recombinase/integrase	-
IF696_RS13375 (2701594)	2701594..2702226	-	633	WP_000616253.1	helix-turn-helix transcriptional regulator	-
IF696_RS13380 (2702400)	2702400..2702612	+	213	WP_000794315.1	helix-turn-helix transcriptional regulator	-
IF696_RS13385 (2702616)	2702616..2702933	+	318	WP_000459698.1	helix-turn-helix domain-containing protein	-
IF696_RS13390 (2702930)	2702930..2703076	+	147	WP_000784875.1	hypothetical protein	-
IF696_RS13395 (2703069)	2703069..2703278	+	210	WP_001058486.1	hypothetical protein	Antitoxin
IF696_RS13400 (2703281)	2703281..2703580	+	300	WP_001103943.1	DUF1474 family protein	Toxin
IF696_RS13405 (2703655)	2703655..2705271	+	1617	WP_000344761.1	hypothetical protein	-
IF696_RS13410 (2705447)	2705447..2706250	+	804	WP_000148374.1	bifunctional DNA primase/polymerase	-
IF696_RS13415 (2706237)	2706237..2706509	+	273	WP_001149387.1	hypothetical protein	-
IF696_RS13420 (2706511)	2706511..2707152	+	642	WP_001019765.1	hypothetical protein	-
IF696_RS13425 (2707499)	2707499..2707840	+	342	WP_001161659.1	hypothetical protein	-
IF696_RS13430 (2707852)	2707852..2708430	+	579	WP_000846292.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11795.24 Da
• Isoelectric Point: 4.5689

>T175225 WP_001103943.1 NZ_CP062420:2703281-2703580 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDA

Nucleotide

• Length: 300 bp

>T175225 NZ_CP081825:3450210-3450560 [Paenibacillus sp. DR312]
TTGATCGTAAAACGTGGTGACGTTTTTTTTGCGGATCTTTCTCCCGTTGTCGGTTCCGAGCAAGGTGGAGTCAGGCCGGT
TCTGGTGATCCAGAATGATATCGGCAACCGGTTCAGTCCAACTTGTATTGTGGCGGCTATCACCGCCCAAATCCAGAAGG
CAAAGCTGCCAACGCATGTGGAAATTGATGCGGCGGCACACGGCTTTGACCGGGACTCGGTTATTTTGCTCGAACAAATA
CGGACGATTGATAAACAGAGGCTGACTGACAAGATTACCCATCTGGACGAGGAGACCATGAAATTGGTCAACGAAGCCTT
ACAGATCAGCCTTGGTTTAATCGATTTTTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT175225 WP_001058486.1 NZ_CP062420:2703069-2703278 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT175225 NZ_CP081825:3449925-3450206 [Paenibacillus sp. DR312]
GTGGCCAACTTGCAGAACACCAAGCGGATCATGATCAGTTTACCTGATTATCTTTTGCAGGAAGTGGATGGCATCGTAGC
GCTGGAGAATTCCAACCGCAGCGAATTGATTAGGCAGGCTATGAAGCTGTATTTAACGGAGCGTAAGAAACGTTACATCC
GTGAAACGATGCAGCGAGGGTACATGGAGATGGCAAAAATTAATCTGACCATGGCATCCGAAGCCTTTCATGCGGAGGAA
GATGCGGACAGCACTCTGGACCGCTTAGTTAGCGGGGTGTAG