Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2629323..2629837 Replicon chromosome
Accession NZ_CP062420
Organism Staphylococcus aureus strain NAS_AN_016

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF696_RS13025 Protein ID WP_000581792.1
Coordinates 2629628..2629837 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF696_RS13020 Protein ID WP_000138932.1
Coordinates 2629323..2629616 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF696_RS13000 (2624794) 2624794..2625435 + 642 WP_000483153.1 thiamine phosphate synthase -
IF696_RS13005 (2625521) 2625521..2626393 + 873 WP_000725802.1 membrane protein insertase YidC -
IF696_RS13010 (2626998) 2626998..2627645 - 648 WP_001187630.1 HD domain-containing protein -
IF696_RS13015 (2627673) 2627673..2629157 - 1485 WP_000571549.1 cardiolipin synthase -
IF696_RS13020 (2629323) 2629323..2629616 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF696_RS13025 (2629628) 2629628..2629837 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF696_RS13030 (2629965) 2629965..2630102 + 138 WP_000828354.1 Lmo0850 family protein -
IF696_RS13035 (2630366) 2630366..2631568 - 1203 WP_001836940.1 FtsW/RodA/SpoVE family cell cycle protein -
IF696_RS13040 (2631886) 2631886..2632956 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF696_RS13045 (2632971) 2632971..2634329 + 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T175223 WP_000581792.1 NZ_CP062420:2629628-2629837 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T175223 NZ_CP081823:1858-2172 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT175223 WP_000138932.1 NZ_CP062420:2629323-2629616 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT175223 NZ_CP081823:1592-1870 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References