Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2666323..2666852 Replicon chromosome
Accession NZ_CP062419
Organism Staphylococcus aureus strain NAS_AN_023

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IF697_RS13110 Protein ID WP_000621175.1
Coordinates 2666490..2666852 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IF697_RS13105 Protein ID WP_000948331.1
Coordinates 2666323..2666493 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF697_RS13075 (2661359) 2661359..2661919 + 561 WP_001092402.1 K(+)-transporting ATPase subunit C -
IF697_RS13080 (2662128) 2662128..2662607 + 480 WP_001287090.1 hypothetical protein -
IF697_RS13085 (2662600) 2662600..2664183 + 1584 WP_001294626.1 PH domain-containing protein -
IF697_RS13090 (2664170) 2664170..2664661 + 492 WP_001205910.1 PH domain-containing protein -
IF697_RS13095 (2664665) 2664665..2665024 + 360 WP_000581197.1 holo-ACP synthase -
IF697_RS13100 (2665090) 2665090..2666238 + 1149 WP_001281142.1 alanine racemase -
IF697_RS13105 (2666323) 2666323..2666493 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IF697_RS13110 (2666490) 2666490..2666852 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IF697_RS13115 (2667201) 2667201..2668202 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
IF697_RS13120 (2668321) 2668321..2668647 + 327 WP_001052491.1 anti-sigma factor antagonist -
IF697_RS13125 (2668649) 2668649..2669128 + 480 WP_001190829.1 anti-sigma B factor RsbW -
IF697_RS13130 (2669103) 2669103..2669873 + 771 WP_240122452.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T175214 WP_000621175.1 NZ_CP062419:2666490-2666852 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T175214 NZ_CP081820:2013403-2013505 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT175214 WP_000948331.1 NZ_CP062419:2666323-2666493 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT175214 NZ_CP081820:c2013512-2013367 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References