Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1613102..1613631 Replicon chromosome
Accession NZ_CP062419
Organism Staphylococcus aureus strain NAS_AN_023

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag IF697_RS07995 Protein ID WP_001103933.1
Coordinates 1613102..1613419 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A2X2M557
Locus tag IF697_RS08000 Protein ID WP_001058488.1
Coordinates 1613422..1613631 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF697_RS07970 (1608217) 1608217..1608558 - 342 WP_001190614.1 hypothetical protein -
IF697_RS07975 (1609094) 1609094..1609735 - 642 WP_064140196.1 pathogenicity island protein -
IF697_RS07980 (1609732) 1609732..1610112 - 381 WP_000356927.1 hypothetical protein -
IF697_RS07985 (1610443) 1610443..1612152 - 1710 WP_000447454.1 DUF927 domain-containing protein -
IF697_RS07990 (1612166) 1612166..1613035 - 870 WP_001002701.1 primase alpha helix C-terminal domain-containing protein -
IF697_RS07995 (1613102) 1613102..1613419 - 318 WP_001103933.1 DUF1474 family protein Toxin
IF697_RS08000 (1613422) 1613422..1613631 - 210 WP_001058488.1 hypothetical protein Antitoxin
IF697_RS08005 (1613624) 1613624..1613770 - 147 WP_000780975.1 hypothetical protein -
IF697_RS08010 (1613817) 1613817..1614077 - 261 WP_001147662.1 hypothetical protein -
IF697_RS08015 (1614079) 1614079..1614276 - 198 WP_000466891.1 helix-turn-helix transcriptional regulator -
IF697_RS08020 (1614420) 1614420..1615043 + 624 WP_000431539.1 helix-turn-helix transcriptional regulator -
IF697_RS08025 (1615139) 1615139..1616275 + 1137 WP_000592973.1 site-specific integrase -
IF697_RS08030 (1616369) 1616369..1617910 - 1542 WP_000424963.1 glutamine-hydrolyzing GMP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sell / sec 1595533..1620707 25174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T175204 WP_001103933.1 NZ_CP062419:c1613419-1613102 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T175204 NZ_CP081816:2789481-2789849 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8287.31 Da        Isoelectric Point: 4.2820

>AT175204 WP_001058488.1 NZ_CP062419:c1613631-1613422 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT175204 NZ_CP081816:2789263-2789484 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTAACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2M557

References