Detailed information of TA system TA175203

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1167523..1168000
• Replicon: chromosome
• Accession: NZ_CP062419
• Organism: Staphylococcus aureus strain NAS_AN_023

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF697_RS05795
• Protein ID: WP_000052076.1
• Coordinates: 1167812..1168000 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF697_RS05790
• Protein ID: WP_001059690.1
• Coordinates: 1167523..1167783 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF697_RS05755 (1162916)	1162916..1163632	-	717	WP_000150012.1	type I 3-dehydroquinate dehydratase	-
IF697_RS05760 (1163780)	1163780..1164202	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF697_RS05765 (1164601)	1164601..1165095	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF697_RS05770 (1165250)	1165250..1165867	+	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
IF697_RS05775 (1165940)	1165940..1166521	-	582	WP_001140693.1	histidine phosphatase family protein	-
IF697_RS05780 (1166746)	1166746..1166982	+	237	WP_000368687.1	hypothetical protein	-
IF697_RS05785 (1166979)	1166979..1167182	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF697_RS05790 (1167523)	1167523..1167783	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF697_RS05795 (1167812)	1167812..1168000	+	189	WP_000052076.1	hypothetical protein	Toxin
IF697_RS05800 (1168188)	1168188..1168757	+	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
IF697_RS05805 (1168845)	1168845..1169129	+	285	WP_001004395.1	hypothetical protein	-
IF697_RS05810 (1169191)	1169191..1169409	+	219	WP_000005886.1	hypothetical protein	-
IF697_RS05815 (1169905)	1169905..1170105	-	201	WP_001059082.1	cold-shock protein	-
IF697_RS05820 (1170462)	1170462..1171148	-	687	WP_001792695.1	thermonuclease family protein	-
IF697_RS05825 (1171489)	1171489..1172010	-	522	WP_000824484.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-112)

Antitoxin

• Predicted DNA-binding protein, ribbon-helix-helix domain (16-47)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T175203 WP_000052076.1 NZ_CP062419:1167812-1168000 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T175203 NZ_CP081816:c2382638-2382255 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT175203 WP_001059690.1 NZ_CP062419:1167523-1167783 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT175203 NZ_CP081816:c2382880-2382638 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56