Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2702895..2703406 Replicon chromosome
Accession NZ_CP062418
Organism Staphylococcus aureus strain NAS_AN_136

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag IF715_RS13380 Protein ID WP_001103943.1
Coordinates 2703107..2703406 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag IF715_RS13375 Protein ID WP_001058486.1
Coordinates 2702895..2703104 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF715_RS13340 (2698194) 2698194..2698478 + 285 WP_000917289.1 co-chaperone GroES -
IF715_RS13345 (2698554) 2698554..2700170 + 1617 WP_000240645.1 chaperonin GroEL -
IF715_RS13350 (2700239) 2700239..2701411 - 1173 WP_000179352.1 tyrosine-type recombinase/integrase -
IF715_RS13355 (2701420) 2701420..2702052 - 633 WP_000616253.1 helix-turn-helix transcriptional regulator -
IF715_RS13360 (2702226) 2702226..2702438 + 213 WP_000794315.1 helix-turn-helix transcriptional regulator -
IF715_RS13365 (2702442) 2702442..2702759 + 318 WP_000459698.1 helix-turn-helix domain-containing protein -
IF715_RS13370 (2702756) 2702756..2702902 + 147 WP_000784875.1 hypothetical protein -
IF715_RS13375 (2702895) 2702895..2703104 + 210 WP_001058486.1 hypothetical protein Antitoxin
IF715_RS13380 (2703107) 2703107..2703406 + 300 WP_001103943.1 DUF1474 family protein Toxin
IF715_RS13385 (2703481) 2703481..2705097 + 1617 WP_000344761.1 hypothetical protein -
IF715_RS13390 (2705273) 2705273..2706076 + 804 WP_000148374.1 bifunctional DNA primase/polymerase -
IF715_RS13395 (2706063) 2706063..2706335 + 273 WP_001149387.1 hypothetical protein -
IF715_RS13400 (2706337) 2706337..2706978 + 642 WP_001019765.1 hypothetical protein -
IF715_RS13405 (2707325) 2707325..2707666 + 342 WP_001161659.1 hypothetical protein -
IF715_RS13410 (2707678) 2707678..2708256 + 579 WP_000846292.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb 2695285..2743407 48122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11795.24 Da        Isoelectric Point: 4.5689

>T175196 WP_001103943.1 NZ_CP062418:2703107-2703406 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDA

Download         Length: 300 bp

>T175196 NZ_CP081813:c4305549-4305376 [Shigella flexneri]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT175196 WP_001058486.1 NZ_CP062418:2702895-2703104 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT175196 NZ_CP081813:c4305873-4305577 [Shigella flexneri]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References