Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2629226..2629740 Replicon chromosome
Accession NZ_CP062418
Organism Staphylococcus aureus strain NAS_AN_136

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF715_RS13005 Protein ID WP_000581792.1
Coordinates 2629531..2629740 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF715_RS13000 Protein ID WP_000138932.1
Coordinates 2629226..2629519 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF715_RS12980 (2624697) 2624697..2625338 + 642 WP_000483153.1 thiamine phosphate synthase -
IF715_RS12985 (2625424) 2625424..2626296 + 873 WP_000725802.1 membrane protein insertase YidC -
IF715_RS12990 (2626901) 2626901..2627548 - 648 WP_001187630.1 HD domain-containing protein -
IF715_RS12995 (2627576) 2627576..2629060 - 1485 WP_000571549.1 cardiolipin synthase -
IF715_RS13000 (2629226) 2629226..2629519 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF715_RS13005 (2629531) 2629531..2629740 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF715_RS13010 (2629868) 2629868..2630005 + 138 WP_000828354.1 Lmo0850 family protein -
IF715_RS13015 (2630269) 2630269..2631471 - 1203 WP_001836940.1 FtsW/RodA/SpoVE family cell cycle protein -
IF715_RS13020 (2631789) 2631789..2632859 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF715_RS13025 (2632874) 2632874..2634232 + 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T175194 WP_000581792.1 NZ_CP062418:2629531-2629740 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T175194 NZ_CP081813:3753396-3753674 [Shigella flexneri]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT175194 WP_000138932.1 NZ_CP062418:2629226-2629519 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT175194 NZ_CP081813:3753133-3753393 [Shigella flexneri]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCATTTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References