Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1156433..1156910 Replicon chromosome
Accession NZ_CP062418
Organism Staphylococcus aureus strain NAS_AN_136

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF715_RS05820 Protein ID WP_000052076.1
Coordinates 1156722..1156910 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF715_RS05815 Protein ID WP_001059690.1
Coordinates 1156433..1156693 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF715_RS05780 (1151826) 1151826..1152542 - 717 WP_240088635.1 type I 3-dehydroquinate dehydratase -
IF715_RS05785 (1152690) 1152690..1153112 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF715_RS05790 (1153511) 1153511..1154005 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF715_RS05795 (1154160) 1154160..1154777 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
IF715_RS05800 (1154850) 1154850..1155431 - 582 WP_001140697.1 histidine phosphatase family protein -
IF715_RS05805 (1155656) 1155656..1155892 + 237 WP_000368687.1 hypothetical protein -
IF715_RS05810 (1155889) 1155889..1156092 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF715_RS05815 (1156433) 1156433..1156693 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF715_RS05820 (1156722) 1156722..1156910 + 189 WP_000052076.1 hypothetical protein Toxin
IF715_RS05825 (1157098) 1157098..1157667 + 570 WP_001106653.1 lipoprotein N-acylation protein LnsA -
IF715_RS05830 (1157755) 1157755..1158039 + 285 WP_001004394.1 hypothetical protein -
IF715_RS05835 (1158101) 1158101..1158319 + 219 WP_000005884.1 hypothetical protein -
IF715_RS05840 (1158814) 1158814..1159014 - 201 WP_001059082.1 cold-shock protein -
IF715_RS05845 (1159371) 1159371..1160057 - 687 WP_001548082.1 thermonuclease family protein -
IF715_RS05850 (1160398) 1160398..1160868 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T175190 WP_000052076.1 NZ_CP062418:1156722-1156910 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T175190 NZ_CP081813:2693174-2693281 [Shigella flexneri]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT175190 WP_001059690.1 NZ_CP062418:1156433-1156693 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT175190 NZ_CP081813:c2693121-2693060 [Shigella flexneri]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References