Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tsbAT/- |
Location | 120125..120901 | Replicon | chromosome |
Accession | NZ_CP062418 | ||
Organism | Staphylococcus aureus strain NAS_AN_136 |
Toxin (Protein)
Gene name | tsbT | Uniprot ID | X5E2E6 |
Locus tag | IF715_RS00765 | Protein ID | WP_000031108.1 |
Coordinates | 120749..120901 (+) | Length | 51 a.a. |
Antitoxin (Protein)
Gene name | tsbA | Uniprot ID | W8U4V4 |
Locus tag | IF715_RS00760 | Protein ID | WP_001251224.1 |
Coordinates | 120125..120724 (+) | Length | 200 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IF715_RS00740 (116040) | 116040..117497 | + | 1458 | WP_000649907.1 | ABC transporter permease subunit | - |
IF715_RS00745 (117490) | 117490..118212 | + | 723 | WP_000590809.1 | amino acid ABC transporter ATP-binding protein | - |
IF715_RS00750 (118364) | 118364..119491 | + | 1128 | WP_240088612.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
IF715_RS00755 (119496) | 119496..119966 | + | 471 | WP_000181394.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
IF715_RS00760 (120125) | 120125..120724 | + | 600 | WP_001251224.1 | glucosamine-6-phosphate isomerase | Antitoxin |
IF715_RS00765 (120749) | 120749..120901 | + | 153 | WP_000031108.1 | SAS053 family protein | Toxin |
IF715_RS00770 (121445) | 121445..121840 | + | 396 | WP_000901023.1 | hypothetical protein | - |
IF715_RS00775 (122036) | 122036..123421 | + | 1386 | WP_000116229.1 | class II fumarate hydratase | - |
IF715_RS00780 (123873) | 123873..124694 | - | 822 | WP_000669376.1 | RluA family pseudouridine synthase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5936.28 Da Isoelectric Point: 3.8962
>T175189 WP_000031108.1 NZ_CP062418:120749-120901 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
Download Length: 153 bp
>T175189 NZ_CP081813:2692638-2692745 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 200 a.a. Molecular weight: 22343.47 Da Isoelectric Point: 5.1445
>AT175189 WP_001251224.1 NZ_CP062418:120125-120724 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
Download Length: 600 bp
>AT175189 NZ_CP081813:c2692591-2692525 [Shigella flexneri]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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