Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1157123..1157600 Replicon chromosome
Accession NZ_CP062417
Organism Staphylococcus aureus strain NAS_AN_143

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF718_RS05745 Protein ID WP_000052076.1
Coordinates 1157412..1157600 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF718_RS05740 Protein ID WP_001059690.1
Coordinates 1157123..1157383 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF718_RS05705 (1152516) 1152516..1153232 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
IF718_RS05710 (1153380) 1153380..1153802 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF718_RS05715 (1154201) 1154201..1154695 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF718_RS05720 (1154850) 1154850..1155467 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
IF718_RS05725 (1155540) 1155540..1156121 - 582 WP_001140693.1 histidine phosphatase family protein -
IF718_RS05730 (1156346) 1156346..1156582 + 237 WP_000349581.1 hypothetical protein -
IF718_RS05735 (1156579) 1156579..1156782 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF718_RS05740 (1157123) 1157123..1157383 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF718_RS05745 (1157412) 1157412..1157600 + 189 WP_000052076.1 hypothetical protein Toxin
IF718_RS05750 (1157788) 1157788..1158357 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF718_RS05755 (1158445) 1158445..1158729 + 285 WP_001004399.1 hypothetical protein -
IF718_RS05760 (1158791) 1158791..1159009 + 219 WP_000005886.1 hypothetical protein -
IF718_RS05765 (1159501) 1159501..1159701 - 201 WP_001059082.1 cold-shock protein -
IF718_RS05770 (1160058) 1160058..1160744 - 687 WP_000141557.1 thermonuclease family protein -
IF718_RS05775 (1161085) 1161085..1161606 - 522 WP_049311898.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1154201..1190739 36538


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T175174 WP_000052076.1 NZ_CP062417:1157412-1157600 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T175174 NZ_CP081791:c2451661-2451179 [Escherichia coli]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT175174 WP_001059690.1 NZ_CP062417:1157123-1157383 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT175174 NZ_CP081791:c2451915-2451649 [Escherichia coli]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References