Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1157123..1157600 | Replicon | chromosome |
| Accession | NZ_CP062417 | ||
| Organism | Staphylococcus aureus strain NAS_AN_143 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | IF718_RS05745 | Protein ID | WP_000052076.1 |
| Coordinates | 1157412..1157600 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | IF718_RS05740 | Protein ID | WP_001059690.1 |
| Coordinates | 1157123..1157383 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF718_RS05705 (1152516) | 1152516..1153232 | - | 717 | WP_000150011.1 | type I 3-dehydroquinate dehydratase | - |
| IF718_RS05710 (1153380) | 1153380..1153802 | + | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| IF718_RS05715 (1154201) | 1154201..1154695 | + | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| IF718_RS05720 (1154850) | 1154850..1155467 | + | 618 | WP_000255551.1 | LysE/ArgO family amino acid transporter | - |
| IF718_RS05725 (1155540) | 1155540..1156121 | - | 582 | WP_001140693.1 | histidine phosphatase family protein | - |
| IF718_RS05730 (1156346) | 1156346..1156582 | + | 237 | WP_000349581.1 | hypothetical protein | - |
| IF718_RS05735 (1156579) | 1156579..1156782 | - | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| IF718_RS05740 (1157123) | 1157123..1157383 | + | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| IF718_RS05745 (1157412) | 1157412..1157600 | + | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| IF718_RS05750 (1157788) | 1157788..1158357 | + | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
| IF718_RS05755 (1158445) | 1158445..1158729 | + | 285 | WP_001004399.1 | hypothetical protein | - |
| IF718_RS05760 (1158791) | 1158791..1159009 | + | 219 | WP_000005886.1 | hypothetical protein | - |
| IF718_RS05765 (1159501) | 1159501..1159701 | - | 201 | WP_001059082.1 | cold-shock protein | - |
| IF718_RS05770 (1160058) | 1160058..1160744 | - | 687 | WP_000141557.1 | thermonuclease family protein | - |
| IF718_RS05775 (1161085) | 1161085..1161606 | - | 522 | WP_049311898.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vWbp | 1154201..1190739 | 36538 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T175174 WP_000052076.1 NZ_CP062417:1157412-1157600 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T175174 NZ_CP081791:c2451661-2451179 [Escherichia coli]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT175174 WP_001059690.1 NZ_CP062417:1157123-1157383 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT175174 NZ_CP081791:c2451915-2451649 [Escherichia coli]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |