175157

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1169655..1170132 Replicon chromosome
Accession NZ_CP062416
Organism Staphylococcus aureus strain NAS_AN_149

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF719_RS05820 Protein ID WP_000052076.1
Coordinates 1169944..1170132 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF719_RS05815 Protein ID WP_001059690.1
Coordinates 1169655..1169915 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF719_RS05780 (1165048) 1165048..1165764 - 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -
IF719_RS05785 (1165912) 1165912..1166334 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF719_RS05790 (1166733) 1166733..1167227 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF719_RS05795 (1167382) 1167382..1167999 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IF719_RS05800 (1168072) 1168072..1168653 - 582 WP_001140693.1 histidine phosphatase family protein -
IF719_RS05805 (1168878) 1168878..1169114 + 237 WP_000368687.1 hypothetical protein -
IF719_RS05810 (1169111) 1169111..1169314 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF719_RS05815 (1169655) 1169655..1169915 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF719_RS05820 (1169944) 1169944..1170132 + 189 WP_000052076.1 hypothetical protein Toxin
IF719_RS05825 (1170320) 1170320..1170889 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF719_RS05830 (1170977) 1170977..1171261 + 285 WP_001004395.1 hypothetical protein -
IF719_RS05835 (1171323) 1171323..1171541 + 219 WP_000005886.1 hypothetical protein -
IF719_RS05840 (1172037) 1172037..1172237 - 201 WP_001059082.1 cold-shock protein -
IF719_RS05845 (1172594) 1172594..1173280 - 687 WP_001792695.1 thermonuclease family protein -
IF719_RS05850 (1173621) 1173621..1174142 - 522 WP_000824484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(92-156)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T175157 WP_000052076.1 NZ_CP062416:1169944-1170132 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T175157 NZ_CP081784:82515-83045 [Escherichia coli]
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATGAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTTACTGACCATCTGAAACGCCAGCACAACAGTAAGATTTTGCGTGGCTATCTGCTCGTGACGAGAGAGG
ATAAACCACGTGTTATGGGGTACTACACGCTGTCTGGCAGCTGCTTTGAGAAAACACTTCTACCCAGCAAAACGCAACAA
AAGCGCGTCCCCTACAAAAATGTGCCGAGCGTGACTTTAGGCCGTCTGGCAATTGATAAAAGCATTCATCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCTATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AAGCGCTGAACGACAACGCCAAAAAATTCTACCTTCGCCTGGGTTTTATACAGTTAAAAGAAGAAAACAGTAATTCGCTC
TTCTACCCGACAAAATCTGTTGAAGAATTGTTCGAAGTAAAAGATGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT175157 WP_001059690.1 NZ_CP062416:1169655-1169915 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT175157 NZ_CP081784:82242-82511 [Escherichia coli]
ATGTCAGCACTGAAAAAGCAGCGCATTGACCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCAATTTCGCAGTTCATGGTCAGTACCGCCTCAGAACGCGCTGCAGAAGTTATTGACCAGCACCGTCGTC
TGCTCCTCAATGAGGAGTCCTGGAACCTGGTTATGGATGCAATCACTAATCCGCCAGTACCGAATGACCGGCTGAAACGC
GCCGCTAACCGTCTCCGGGAACTGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References