Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2793237..2793751 Replicon chromosome
Accession NZ_CP062415
Organism Staphylococcus aureus strain NAS_AN_150

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag IF720_RS13885 Protein ID WP_000581791.1
Coordinates 2793542..2793751 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag IF720_RS13880 Protein ID WP_000138934.1
Coordinates 2793237..2793530 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF720_RS13855 (2788700) 2788700..2789341 + 642 WP_000483150.1 thiamine phosphate synthase -
IF720_RS13860 (2789427) 2789427..2790299 + 873 WP_000725802.1 membrane protein insertase YidC -
IF720_RS13865 (2790456) 2790456..2790755 - 300 WP_001793952.1 hypothetical protein -
IF720_RS13870 (2790912) 2790912..2791559 - 648 WP_001187612.1 HD domain-containing protein -
IF720_RS13875 (2791587) 2791587..2793071 - 1485 WP_000571560.1 cardiolipin synthase -
IF720_RS13880 (2793237) 2793237..2793530 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF720_RS13885 (2793542) 2793542..2793751 + 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
IF720_RS13890 (2793879) 2793879..2794016 + 138 WP_000828354.1 Lmo0850 family protein -
IF720_RS13895 (2794428) 2794428..2795111 + 684 Protein_2707 transposase -
IF720_RS13900 (2795272) 2795272..2796474 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF720_RS13905 (2796792) 2796792..2797862 + 1071 WP_000159639.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T175148 WP_000581791.1 NZ_CP062415:2793542-2793751 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T175148 NZ_CP081782:3902789-3903130 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT175148 WP_000138934.1 NZ_CP062415:2793237-2793530 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT175148 NZ_CP081782:3902451-3902768 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References