Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsdAT/- |
Location | 2651027..2651541 | Replicon | chromosome |
Accession | NZ_CP062414 | ||
Organism | Staphylococcus aureus strain NAS_AN_175 |
Toxin (Protein)
Gene name | TsdT | Uniprot ID | T1YA99 |
Locus tag | IF723_RS13040 | Protein ID | WP_000581792.1 |
Coordinates | 2651332..2651541 (+) | Length | 70 a.a. |
Antitoxin (Protein)
Gene name | TsdA | Uniprot ID | W8UW13 |
Locus tag | IF723_RS13035 | Protein ID | WP_000138932.1 |
Coordinates | 2651027..2651320 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IF723_RS13015 (2646631) | 2646631..2647272 | + | 642 | WP_000483153.1 | thiamine phosphate synthase | - |
IF723_RS13020 (2647358) | 2647358..2648230 | + | 873 | WP_000725802.1 | membrane protein insertase YidC | - |
IF723_RS13025 (2648702) | 2648702..2649349 | - | 648 | WP_001187630.1 | HD domain-containing protein | - |
IF723_RS13030 (2649377) | 2649377..2650861 | - | 1485 | WP_000571549.1 | cardiolipin synthase | - |
IF723_RS13035 (2651027) | 2651027..2651320 | + | 294 | WP_000138932.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
IF723_RS13040 (2651332) | 2651332..2651541 | + | 210 | WP_000581792.1 | heavy metal-associated domain-containing protein | Toxin |
IF723_RS13045 (2651669) | 2651669..2651806 | + | 138 | WP_000828354.1 | Lmo0850 family protein | - |
IF723_RS13050 (2652070) | 2652070..2653272 | - | 1203 | WP_001109939.1 | FtsW/RodA/SpoVE family cell cycle protein | - |
IF723_RS13055 (2653590) | 2653590..2654660 | + | 1071 | WP_000159631.1 | D-alanine--D-alanine ligase | - |
IF723_RS13060 (2654675) | 2654675..2656033 | + | 1359 | WP_000611470.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7843.77 Da Isoelectric Point: 4.1008
>T175129 WP_000581792.1 NZ_CP062414:2651332-2651541 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
Download Length: 210 bp
>T175129 NZ_CP081775:209159-209464 [Escherichia coli]
ATGCAATTCATCATCTACGAATATAAGCGGGTAAGCCATTACAAAATGTTTGTCGATGTGCAAAGCGATATAGTTGATAC
ACCAGGCCGTCGTATGGTTATACCGCTGATTGAATCCCATCACTTGTCTGAAATCGTAAACAGCTCCCTGTTCCCGGTAG
TCAGAATTAACGATGAAGACTACCGGGTAATGACTACCGAGCTATCAAGCGTGTCTGCGGCGGTTACTGGTGAAGCTATT
GCCGATGTCAGCTCTGATGCAGATGCGATAAAAAATGCTATCAACCTTATGTTCTGGGGAATTTAA
ATGCAATTCATCATCTACGAATATAAGCGGGTAAGCCATTACAAAATGTTTGTCGATGTGCAAAGCGATATAGTTGATAC
ACCAGGCCGTCGTATGGTTATACCGCTGATTGAATCCCATCACTTGTCTGAAATCGTAAACAGCTCCCTGTTCCCGGTAG
TCAGAATTAACGATGAAGACTACCGGGTAATGACTACCGAGCTATCAAGCGTGTCTGCGGCGGTTACTGGTGAAGCTATT
GCCGATGTCAGCTCTGATGCAGATGCGATAAAAAATGCTATCAACCTTATGTTCTGGGGAATTTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11197.82 Da Isoelectric Point: 6.2243
>AT175129 WP_000138932.1 NZ_CP062414:2651027-2651320 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
Download Length: 294 bp
>AT175129 NZ_CP081775:208939-209157 [Escherichia coli]
ATGAAACACAGAGTCAGCGTTACAGTAGACAGAGAAAATTATCAGGTTCTGAGTTCTGCCGGAATCAACATTTCAGGGCT
GGTCAATGAGGTCATAGGCAAAGAAGCACGGAAGATAAAAGCCGAGCAATGGAAAGCGGACAACCGCGCAGGTATGGAGG
AAGTCGCAAACTTCATCGCGCAGCATGGCTCCTTTGCCGAAGAAAACAGGAACTGGTGA
ATGAAACACAGAGTCAGCGTTACAGTAGACAGAGAAAATTATCAGGTTCTGAGTTCTGCCGGAATCAACATTTCAGGGCT
GGTCAATGAGGTCATAGGCAAAGAAGCACGGAAGATAAAAGCCGAGCAATGGAAAGCGGACAACCGCGCAGGTATGGAGG
AAGTCGCAAACTTCATCGCGCAGCATGGCTCCTTTGCCGAAGAAAACAGGAACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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