Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1613933..1614462 Replicon chromosome
Accession NZ_CP062414
Organism Staphylococcus aureus strain NAS_AN_175

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag IF723_RS08020 Protein ID WP_001103933.1
Coordinates 1613933..1614250 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A2X2M557
Locus tag IF723_RS08025 Protein ID WP_001058488.1
Coordinates 1614253..1614462 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF723_RS07995 (1609048) 1609048..1609389 - 342 WP_001190614.1 hypothetical protein -
IF723_RS08000 (1609925) 1609925..1610566 - 642 WP_064140196.1 pathogenicity island protein -
IF723_RS08005 (1610563) 1610563..1610943 - 381 WP_000356927.1 hypothetical protein -
IF723_RS08010 (1611274) 1611274..1612983 - 1710 WP_000447454.1 DUF927 domain-containing protein -
IF723_RS08015 (1612997) 1612997..1613866 - 870 WP_001002701.1 primase alpha helix C-terminal domain-containing protein -
IF723_RS08020 (1613933) 1613933..1614250 - 318 WP_001103933.1 DUF1474 family protein Toxin
IF723_RS08025 (1614253) 1614253..1614462 - 210 WP_001058488.1 hypothetical protein Antitoxin
IF723_RS08030 (1614455) 1614455..1614601 - 147 WP_000780975.1 hypothetical protein -
IF723_RS08035 (1614648) 1614648..1614908 - 261 WP_001147662.1 hypothetical protein -
IF723_RS08040 (1614910) 1614910..1615107 - 198 WP_000466891.1 helix-turn-helix transcriptional regulator -
IF723_RS08045 (1615197) 1615197..1615874 + 678 WP_239858572.1 helix-turn-helix transcriptional regulator -
IF723_RS08050 (1615970) 1615970..1617106 + 1137 WP_000592973.1 site-specific integrase -
IF723_RS08055 (1617200) 1617200..1618741 - 1542 WP_000424963.1 glutamine-hydrolyzing GMP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sell / sec 1596365..1621538 25173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T175121 WP_001103933.1 NZ_CP062414:c1614250-1613933 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T175121 NZ_CP081774:2935548-2935655 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8287.31 Da        Isoelectric Point: 4.2820

>AT175121 WP_001058488.1 NZ_CP062414:c1614462-1614253 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT175121 NZ_CP081774:c2935498-2935435 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2M557

References