Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1170033..1170510 Replicon chromosome
Accession NZ_CP062414
Organism Staphylococcus aureus strain NAS_AN_175

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF723_RS05825 Protein ID WP_000052076.1
Coordinates 1170322..1170510 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF723_RS05820 Protein ID WP_001059690.1
Coordinates 1170033..1170293 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF723_RS05785 (1165426) 1165426..1166142 - 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -
IF723_RS05790 (1166290) 1166290..1166712 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF723_RS05795 (1167111) 1167111..1167605 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF723_RS05800 (1167760) 1167760..1168377 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IF723_RS05805 (1168450) 1168450..1169031 - 582 WP_001140693.1 histidine phosphatase family protein -
IF723_RS05810 (1169256) 1169256..1169492 + 237 WP_000368687.1 hypothetical protein -
IF723_RS05815 (1169489) 1169489..1169692 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF723_RS05820 (1170033) 1170033..1170293 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF723_RS05825 (1170322) 1170322..1170510 + 189 WP_000052076.1 hypothetical protein Toxin
IF723_RS05830 (1170698) 1170698..1171267 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF723_RS05835 (1171355) 1171355..1171639 + 285 WP_001004395.1 hypothetical protein -
IF723_RS05840 (1171701) 1171701..1171919 + 219 WP_000005886.1 hypothetical protein -
IF723_RS05845 (1172415) 1172415..1172615 - 201 WP_001059082.1 cold-shock protein -
IF723_RS05850 (1172972) 1172972..1173658 - 687 WP_001792695.1 thermonuclease family protein -
IF723_RS05855 (1173999) 1173999..1174520 - 522 WP_000824484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T175120 WP_000052076.1 NZ_CP062414:1170322-1170510 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T175120 NZ_CP081774:2935013-2935120 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT175120 WP_001059690.1 NZ_CP062414:1170033-1170293 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT175120 NZ_CP081774:c2934966-2934900 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References