Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2683281..2683795 Replicon chromosome
Accession NZ_CP062413
Organism Staphylococcus aureus strain NAS_AN_176

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF724_RS13300 Protein ID WP_000581792.1
Coordinates 2683586..2683795 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF724_RS13295 Protein ID WP_000138932.1
Coordinates 2683281..2683574 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF724_RS13275 (2678444) 2678444..2679085 + 642 WP_000483153.1 thiamine phosphate synthase -
IF724_RS13280 (2679171) 2679171..2680043 + 873 WP_240104171.1 membrane protein insertase YidC -
IF724_RS13285 (2680956) 2680956..2681603 - 648 WP_001187630.1 HD domain-containing protein -
IF724_RS13290 (2681631) 2681631..2683115 - 1485 WP_000571549.1 cardiolipin synthase -
IF724_RS13295 (2683281) 2683281..2683574 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF724_RS13300 (2683586) 2683586..2683795 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF724_RS13305 (2683923) 2683923..2684060 + 138 WP_000828354.1 Lmo0850 family protein -
IF724_RS13310 (2684324) 2684324..2685526 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF724_RS13315 (2685844) 2685844..2686914 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF724_RS13320 (2686929) 2686929..2688287 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T175111 WP_000581792.1 NZ_CP062413:2683586-2683795 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T175111 NZ_CP081774:912709-913116 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT175111 WP_000138932.1 NZ_CP062413:2683281-2683574 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT175111 NZ_CP081774:912462-912728 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References