Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2650844..2651358 Replicon chromosome
Accession NZ_CP062412
Organism Staphylococcus aureus strain NAS_AN_181

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF725_RS13030 Protein ID WP_000581792.1
Coordinates 2651149..2651358 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF725_RS13025 Protein ID WP_000138932.1
Coordinates 2650844..2651137 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF725_RS13005 (2646448) 2646448..2647089 + 642 WP_000483153.1 thiamine phosphate synthase -
IF725_RS13010 (2647175) 2647175..2648047 + 873 WP_000725802.1 membrane protein insertase YidC -
IF725_RS13015 (2648519) 2648519..2649166 - 648 WP_001187630.1 HD domain-containing protein -
IF725_RS13020 (2649194) 2649194..2650678 - 1485 WP_000571549.1 cardiolipin synthase -
IF725_RS13025 (2650844) 2650844..2651137 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF725_RS13030 (2651149) 2651149..2651358 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF725_RS13035 (2651486) 2651486..2651623 + 138 WP_000828354.1 Lmo0850 family protein -
IF725_RS13040 (2651887) 2651887..2653089 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF725_RS13045 (2653407) 2653407..2654477 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF725_RS13050 (2654492) 2654492..2655850 + 1359 WP_000611470.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T175090 WP_000581792.1 NZ_CP062412:2651149-2651358 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T175090 NZ_CP081767:2241994-2242097 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT175090 WP_000138932.1 NZ_CP062412:2650844-2651137 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT175090 NZ_CP081767:c2242135-2241864 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References