Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1613079..1613608 Replicon chromosome
Accession NZ_CP062412
Organism Staphylococcus aureus strain NAS_AN_181

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag IF725_RS08005 Protein ID WP_001103933.1
Coordinates 1613079..1613396 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A2X2M557
Locus tag IF725_RS08010 Protein ID WP_001058488.1
Coordinates 1613399..1613608 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF725_RS07980 (1608194) 1608194..1608535 - 342 WP_001190614.1 hypothetical protein -
IF725_RS07985 (1609071) 1609071..1609712 - 642 WP_064140196.1 pathogenicity island protein -
IF725_RS07990 (1609709) 1609709..1610089 - 381 WP_000356927.1 hypothetical protein -
IF725_RS07995 (1610420) 1610420..1612129 - 1710 WP_000447454.1 DUF927 domain-containing protein -
IF725_RS08000 (1612143) 1612143..1613012 - 870 WP_001002701.1 primase alpha helix C-terminal domain-containing protein -
IF725_RS08005 (1613079) 1613079..1613396 - 318 WP_001103933.1 DUF1474 family protein Toxin
IF725_RS08010 (1613399) 1613399..1613608 - 210 WP_001058488.1 hypothetical protein Antitoxin
IF725_RS08015 (1613601) 1613601..1613747 - 147 WP_000780975.1 hypothetical protein -
IF725_RS08020 (1613794) 1613794..1614054 - 261 WP_001147662.1 hypothetical protein -
IF725_RS08025 (1614056) 1614056..1614253 - 198 WP_000466891.1 helix-turn-helix transcriptional regulator -
IF725_RS08030 (1614397) 1614397..1615020 + 624 WP_000431539.1 helix-turn-helix transcriptional regulator -
IF725_RS08035 (1615116) 1615116..1616252 + 1137 WP_000592973.1 site-specific integrase -
IF725_RS08040 (1616346) 1616346..1617887 - 1542 WP_000424963.1 glutamine-hydrolyzing GMP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sell / sec 1595511..1620684 25173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T175081 WP_001103933.1 NZ_CP062412:c1613396-1613079 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T175081 NZ_CP081767:322300-322575 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8287.31 Da        Isoelectric Point: 4.2820

>AT175081 WP_001058488.1 NZ_CP062412:c1613608-1613399 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT175081 NZ_CP081767:322572-322931 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2M557

References