Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1169265..1169742 Replicon chromosome
Accession NZ_CP062412
Organism Staphylococcus aureus strain NAS_AN_181

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF725_RS05810 Protein ID WP_000052076.1
Coordinates 1169554..1169742 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF725_RS05805 Protein ID WP_001059690.1
Coordinates 1169265..1169525 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF725_RS05770 (1164658) 1164658..1165374 - 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -
IF725_RS05775 (1165522) 1165522..1165944 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF725_RS05780 (1166343) 1166343..1166837 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF725_RS05785 (1166992) 1166992..1167609 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IF725_RS05790 (1167682) 1167682..1168263 - 582 WP_001140693.1 histidine phosphatase family protein -
IF725_RS05795 (1168488) 1168488..1168724 + 237 WP_000368687.1 hypothetical protein -
IF725_RS05800 (1168721) 1168721..1168924 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF725_RS05805 (1169265) 1169265..1169525 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF725_RS05810 (1169554) 1169554..1169742 + 189 WP_000052076.1 hypothetical protein Toxin
IF725_RS05815 (1169930) 1169930..1170499 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF725_RS05820 (1170587) 1170587..1170871 + 285 WP_001004395.1 hypothetical protein -
IF725_RS05825 (1170933) 1170933..1171151 + 219 WP_000005886.1 hypothetical protein -
IF725_RS05830 (1171647) 1171647..1171847 - 201 WP_001059082.1 cold-shock protein -
IF725_RS05835 (1172204) 1172204..1172890 - 687 WP_001792695.1 thermonuclease family protein -
IF725_RS05840 (1173231) 1173231..1173752 - 522 WP_000824484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T175080 WP_000052076.1 NZ_CP062412:1169554-1169742 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T175080 NZ_CP062412:1169554-1169742 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT175080 WP_001059690.1 NZ_CP062412:1169265-1169525 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT175080 NZ_CP062412:1169265-1169525 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References