Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2669973..2670487 Replicon chromosome
Accession NZ_CP062411
Organism Staphylococcus aureus strain NAS_AN_204

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF728_RS13290 Protein ID WP_000581792.1
Coordinates 2670278..2670487 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF728_RS13285 Protein ID WP_000138932.1
Coordinates 2669973..2670266 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF728_RS13265 (2665136) 2665136..2665777 + 642 WP_000483153.1 thiamine phosphate synthase -
IF728_RS13270 (2665863) 2665863..2666735 + 873 WP_000725802.1 membrane protein insertase YidC -
IF728_RS13275 (2667648) 2667648..2668295 - 648 WP_001187630.1 HD domain-containing protein -
IF728_RS13280 (2668323) 2668323..2669807 - 1485 WP_000571549.1 cardiolipin synthase -
IF728_RS13285 (2669973) 2669973..2670266 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF728_RS13290 (2670278) 2670278..2670487 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF728_RS13295 (2670615) 2670615..2670752 + 138 WP_000828354.1 Lmo0850 family protein -
IF728_RS13300 (2671016) 2671016..2672218 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF728_RS13305 (2672536) 2672536..2673606 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF728_RS13310 (2673621) 2673621..2674979 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T175071 WP_000581792.1 NZ_CP062411:2670278-2670487 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T175071 NZ_CP081762:c4253160-4252873 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT175071 WP_000138932.1 NZ_CP062411:2669973-2670266 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT175071 NZ_CP081762:c4252886-4252584 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References