Detailed information of TA system TA175062

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1199860..1200337
• Replicon: chromosome
• Accession: NZ_CP062411
• Organism: Staphylococcus aureus strain NAS_AN_204

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF728_RS06100
• Protein ID: WP_000052076.1
• Coordinates: 1200149..1200337 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF728_RS06095
• Protein ID: WP_001059690.1
• Coordinates: 1199860..1200120 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF728_RS06060 (1195253)	1195253..1195969	-	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-
IF728_RS06065 (1196117)	1196117..1196539	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF728_RS06070 (1196938)	1196938..1197432	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF728_RS06075 (1197587)	1197587..1198204	+	618	WP_000255551.1	LysE/ArgO family amino acid transporter	-
IF728_RS06080 (1198277)	1198277..1198858	-	582	WP_001140693.1	histidine phosphatase family protein	-
IF728_RS06085 (1199083)	1199083..1199319	+	237	WP_000349581.1	hypothetical protein	-
IF728_RS06090 (1199316)	1199316..1199519	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF728_RS06095 (1199860)	1199860..1200120	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF728_RS06100 (1200149)	1200149..1200337	+	189	WP_000052076.1	hypothetical protein	Toxin
IF728_RS06105 (1200525)	1200525..1201094	+	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
IF728_RS06110 (1201182)	1201182..1201466	+	285	WP_001004399.1	hypothetical protein	-
IF728_RS06115 (1201528)	1201528..1201746	+	219	WP_000005886.1	hypothetical protein	-
IF728_RS06120 (1202238)	1202238..1202438	-	201	WP_001059082.1	cold-shock protein	-
IF728_RS06125 (1202795)	1202795..1203481	-	687	WP_000141557.1	thermonuclease family protein	-
IF728_RS06130 (1203822)	1203822..1204343	-	522	WP_049311898.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T175062 WP_000052076.1 NZ_CP062411:1200149-1200337 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T175062 NZ_CP081762:1991878-1992132 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT175062 WP_001059690.1 NZ_CP062411:1199860-1200120 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT175062 NZ_CP081762:1991630-1991881 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56