Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2687230..2687744 Replicon chromosome
Accession NZ_CP062410
Organism Staphylococcus aureus strain NAS_AN_205

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF729_RS13315 Protein ID WP_000581792.1
Coordinates 2687535..2687744 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF729_RS13310 Protein ID WP_000138932.1
Coordinates 2687230..2687523 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF729_RS13290 (2682393) 2682393..2683034 + 642 WP_000483153.1 thiamine phosphate synthase -
IF729_RS13295 (2683120) 2683120..2683992 + 873 WP_000725802.1 membrane protein insertase YidC -
IF729_RS13300 (2684905) 2684905..2685552 - 648 WP_001187630.1 HD domain-containing protein -
IF729_RS13305 (2685580) 2685580..2687064 - 1485 WP_000571549.1 cardiolipin synthase -
IF729_RS13310 (2687230) 2687230..2687523 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF729_RS13315 (2687535) 2687535..2687744 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF729_RS13320 (2687872) 2687872..2688009 + 138 WP_000828354.1 Lmo0850 family protein -
IF729_RS13325 (2688273) 2688273..2689475 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF729_RS13330 (2689793) 2689793..2690863 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF729_RS13335 (2690878) 2690878..2692236 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T175054 WP_000581792.1 NZ_CP062410:2687535-2687744 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T175054 NZ_CP081762:c661624-661160 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGATGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT175054 WP_000138932.1 NZ_CP062410:2687230-2687523 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT175054 NZ_CP081762:c661959-661624 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References