175045

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1198444..1198921 Replicon chromosome
Accession NZ_CP062410
Organism Staphylococcus aureus strain NAS_AN_205

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF729_RS06050 Protein ID WP_000052076.1
Coordinates 1198733..1198921 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF729_RS06045 Protein ID WP_001059690.1
Coordinates 1198444..1198704 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF729_RS06010 (1193837) 1193837..1194553 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
IF729_RS06015 (1194701) 1194701..1195123 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF729_RS06020 (1195522) 1195522..1196016 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF729_RS06025 (1196171) 1196171..1196788 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
IF729_RS06030 (1196861) 1196861..1197442 - 582 WP_001140693.1 histidine phosphatase family protein -
IF729_RS06035 (1197667) 1197667..1197903 + 237 WP_000349581.1 hypothetical protein -
IF729_RS06040 (1197900) 1197900..1198103 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF729_RS06045 (1198444) 1198444..1198704 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF729_RS06050 (1198733) 1198733..1198921 + 189 WP_000052076.1 hypothetical protein Toxin
IF729_RS06055 (1199109) 1199109..1199678 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF729_RS06060 (1199766) 1199766..1200050 + 285 WP_001004399.1 hypothetical protein -
IF729_RS06065 (1200112) 1200112..1200330 + 219 WP_000005886.1 hypothetical protein -
IF729_RS06070 (1200822) 1200822..1201022 - 201 WP_001059082.1 cold-shock protein -
IF729_RS06075 (1201379) 1201379..1202065 - 687 WP_000141557.1 thermonuclease family protein -
IF729_RS06080 (1202406) 1202406..1202927 - 522 WP_240053148.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T175045 WP_000052076.1 NZ_CP062410:1198733-1198921 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T175045 NZ_CP081742:c4436320-4436147 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT175045 WP_001059690.1 NZ_CP062410:1198444-1198704 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT175045 NZ_CP081742:c4436644-4436348 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References