Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2661049..2661578 Replicon chromosome
Accession NZ_CP062409
Organism Staphylococcus aureus strain NAS_AN_239

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IF734_RS13085 Protein ID WP_000621175.1
Coordinates 2661216..2661578 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IF734_RS13080 Protein ID WP_000948331.1
Coordinates 2661049..2661219 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF734_RS13050 (2656086) 2656086..2656646 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
IF734_RS13055 (2656854) 2656854..2657333 + 480 WP_001287087.1 hypothetical protein -
IF734_RS13060 (2657326) 2657326..2658909 + 1584 WP_001294626.1 PH domain-containing protein -
IF734_RS13065 (2658896) 2658896..2659387 + 492 WP_001205912.1 PH domain-containing protein -
IF734_RS13070 (2659391) 2659391..2659750 + 360 WP_000581197.1 holo-ACP synthase -
IF734_RS13075 (2659816) 2659816..2660964 + 1149 WP_001281154.1 alanine racemase -
IF734_RS13080 (2661049) 2661049..2661219 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IF734_RS13085 (2661216) 2661216..2661578 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IF734_RS13090 (2661928) 2661928..2662929 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
IF734_RS13095 (2663048) 2663048..2663374 + 327 WP_001052491.1 anti-sigma factor antagonist -
IF734_RS13100 (2663376) 2663376..2663855 + 480 WP_001190829.1 anti-sigma B factor RsbW -
IF734_RS13105 (2663830) 2663830..2664600 + 771 WP_001041111.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T175037 WP_000621175.1 NZ_CP062409:2661216-2661578 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T175037 NZ_CP081742:2906637-2906744 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT175037 WP_000948331.1 NZ_CP062409:2661049-2661219 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT175037 NZ_CP081742:c2906590-2906524 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References