Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2639805..2640319 Replicon chromosome
Accession NZ_CP062409
Organism Staphylococcus aureus strain NAS_AN_239

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF734_RS12985 Protein ID WP_000581792.1
Coordinates 2640110..2640319 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF734_RS12980 Protein ID WP_000138932.1
Coordinates 2639805..2640098 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF734_RS12960 (2634968) 2634968..2635609 + 642 WP_000483153.1 thiamine phosphate synthase -
IF734_RS12965 (2635695) 2635695..2636567 + 873 WP_000725802.1 membrane protein insertase YidC -
IF734_RS12970 (2637480) 2637480..2638127 - 648 WP_001187630.1 HD domain-containing protein -
IF734_RS12975 (2638155) 2638155..2639639 - 1485 WP_000571549.1 cardiolipin synthase -
IF734_RS12980 (2639805) 2639805..2640098 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF734_RS12985 (2640110) 2640110..2640319 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF734_RS12990 (2640447) 2640447..2640584 + 138 WP_000828354.1 Lmo0850 family protein -
IF734_RS12995 (2640848) 2640848..2642050 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF734_RS13000 (2642368) 2642368..2643438 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF734_RS13005 (2643453) 2643453..2644811 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T175036 WP_000581792.1 NZ_CP062409:2640110-2640319 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T175036 NZ_CP081742:c2631987-2631811 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT175036 WP_000138932.1 NZ_CP062409:2639805-2640098 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT175036 NZ_CP081742:c2631765-2631349 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References