175028

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2266079..2266602 Replicon chromosome
Accession NZ_CP062409
Organism Staphylococcus aureus strain NAS_AN_239

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag IF734_RS11040 Protein ID WP_000074049.1
Coordinates 2266336..2266602 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF734_RS11035 Protein ID WP_000587616.1
Coordinates 2266079..2266336 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF734_RS11020 (2262577) 2262577..2263326 - 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -
IF734_RS11025 (2263521) 2263521..2265098 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
IF734_RS11030 (2265266) 2265266..2265721 - 456 WP_000732076.1 DUF1307 domain-containing protein -
IF734_RS11035 (2266079) 2266079..2266336 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF734_RS11040 (2266336) 2266336..2266602 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
IF734_RS11045 (2266957) 2266957..2268033 + 1077 WP_001076673.1 M42 family metallopeptidase -
IF734_RS11050 (2268281) 2268281..2268943 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
IF734_RS11055 (2268936) 2268936..2269712 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
IF734_RS11060 (2270108) 2270108..2271295 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T175028 WP_000074049.1 NZ_CP062409:2266336-2266602 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T175028 NZ_CP081742:819739-820035 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT175028 WP_000587616.1 NZ_CP062409:2266079-2266336 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT175028 NZ_CP081742:820037-820432 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References