Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2729824..2730338 Replicon chromosome
Accession NZ_CP062408
Organism Staphylococcus aureus strain NAS_AN_247

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF735_RS13550 Protein ID WP_000581792.1
Coordinates 2730129..2730338 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF735_RS13545 Protein ID WP_000138932.1
Coordinates 2729824..2730117 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF735_RS13525 (2725428) 2725428..2726069 + 642 WP_000483153.1 thiamine phosphate synthase -
IF735_RS13530 (2726155) 2726155..2727027 + 873 WP_000725802.1 membrane protein insertase YidC -
IF735_RS13535 (2727499) 2727499..2728146 - 648 WP_001187630.1 HD domain-containing protein -
IF735_RS13540 (2728174) 2728174..2729658 - 1485 WP_000571549.1 cardiolipin synthase -
IF735_RS13545 (2729824) 2729824..2730117 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF735_RS13550 (2730129) 2730129..2730338 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF735_RS13555 (2730466) 2730466..2730603 + 138 WP_000828354.1 Lmo0850 family protein -
IF735_RS13560 (2730867) 2730867..2732069 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF735_RS13565 (2732387) 2732387..2733457 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF735_RS13570 (2733472) 2733472..2734830 + 1359 WP_000611470.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T175019 WP_000581792.1 NZ_CP062408:2730129-2730338 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T175019 NZ_CP081725:c107584-107168 [Escherichia coli]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTGCCGGATCTGGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT175019 WP_000138932.1 NZ_CP062408:2729824-2730117 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT175019 NZ_CP081725:c107811-107581 [Escherichia coli]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References