Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1209617..1210094 Replicon chromosome
Accession NZ_CP062408
Organism Staphylococcus aureus strain NAS_AN_247

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF735_RS06125 Protein ID WP_000052076.1
Coordinates 1209906..1210094 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF735_RS06120 Protein ID WP_001059690.1
Coordinates 1209617..1209877 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF735_RS06085 (1205010) 1205010..1205726 - 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -
IF735_RS06090 (1205874) 1205874..1206296 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF735_RS06095 (1206695) 1206695..1207189 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF735_RS06100 (1207344) 1207344..1207961 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IF735_RS06105 (1208034) 1208034..1208615 - 582 WP_001140693.1 histidine phosphatase family protein -
IF735_RS06110 (1208840) 1208840..1209076 + 237 WP_000368687.1 hypothetical protein -
IF735_RS06115 (1209073) 1209073..1209276 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF735_RS06120 (1209617) 1209617..1209877 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF735_RS06125 (1209906) 1209906..1210094 + 189 WP_000052076.1 hypothetical protein Toxin
IF735_RS06130 (1210282) 1210282..1210851 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF735_RS06135 (1210939) 1210939..1211223 + 285 WP_001004395.1 hypothetical protein -
IF735_RS06140 (1211285) 1211285..1211503 + 219 WP_000005886.1 hypothetical protein -
IF735_RS06145 (1211999) 1211999..1212199 - 201 WP_001059082.1 cold-shock protein -
IF735_RS06150 (1212556) 1212556..1213242 - 687 WP_001792695.1 thermonuclease family protein -
IF735_RS06155 (1213583) 1213583..1214104 - 522 WP_000824484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T175010 WP_000052076.1 NZ_CP062408:1209906-1210094 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T175010 NZ_CP081724:2907171-2907278 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT175010 WP_001059690.1 NZ_CP062408:1209617-1209877 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT175010 NZ_CP081724:c2907121-2907058 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References