Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2206782..2207296 Replicon chromosome
Accession NZ_CP062407
Organism Staphylococcus aureus strain NAS_NP_181

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF751_RS10610 Protein ID WP_000581792.1
Coordinates 2207087..2207296 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag IF751_RS10605 Protein ID WP_000138934.1
Coordinates 2206782..2207075 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF751_RS10585 (2202044) 2202044..2202685 + 642 WP_000483165.1 thiamine phosphate synthase -
IF751_RS10590 (2202771) 2202771..2203643 + 873 WP_000725802.1 membrane protein insertase YidC -
IF751_RS10595 (2204457) 2204457..2205104 - 648 WP_001187619.1 HD domain-containing protein -
IF751_RS10600 (2205132) 2205132..2206616 - 1485 WP_020977447.1 cardiolipin synthase -
IF751_RS10605 (2206782) 2206782..2207075 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF751_RS10610 (2207087) 2207087..2207296 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF751_RS10615 (2207425) 2207425..2207562 + 138 WP_000828354.1 Lmo0850 family protein -
IF751_RS10620 (2207826) 2207826..2209028 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF751_RS10625 (2209346) 2209346..2210416 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF751_RS10630 (2210431) 2210431..2211789 + 1359 WP_000611467.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174994 WP_000581792.1 NZ_CP062407:2207087-2207296 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174994 NZ_CP081721:41230-41535 [Escherichia coli]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGTTGCTATCGTCTGTTCGTGGATGTACAGAGTGACATCATCGATAC
CCCCGGGCGGCGCATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTTTCGGATAAGGTCTCCCGTGATCTCTATCCGGTGG
TGCACATCGGGGACGACAGCTATCGCCTGATGACCACGGACATGGCCAGCGTCACGGCCTCTGTCACCGGGGAGGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT174994 WP_000138934.1 NZ_CP062407:2206782-2207075 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174994 NZ_CP081721:41010-41228 [Escherichia coli]
ATGAAGCAGCGCATCACCGTCACAATAGACAGCGACAGTTATCAGTTACTGAAATCCGCGGACGTCAATATATCCGGTCT
GGTGAACACGGCCATGCAGAATGAGGCCCGCCGTTTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGGTTTATTGAAATGAACGGTTCATTCGCCGAAGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References