Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 687689..688166 Replicon chromosome
Accession NZ_CP062407
Organism Staphylococcus aureus strain NAS_NP_181

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF751_RS03250 Protein ID WP_000052076.1
Coordinates 687978..688166 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF751_RS03245 Protein ID WP_001059690.1
Coordinates 687689..687949 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF751_RS03210 (682945) 682945..683661 - 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -
IF751_RS03215 (683809) 683809..684231 + 423 WP_020977095.1 organic hydroperoxide resistance protein -
IF751_RS03220 (684630) 684630..685124 + 495 WP_000569881.1 GNAT family N-acetyltransferase -
IF751_RS03225 (685417) 685417..686034 + 618 WP_020977094.1 LysE/ArgO family amino acid transporter -
IF751_RS03230 (686107) 686107..686688 - 582 WP_001140696.1 histidine phosphatase family protein -
IF751_RS03235 (686913) 686913..687149 + 237 WP_000368687.1 hypothetical protein -
IF751_RS03240 (687146) 687146..687349 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF751_RS03245 (687689) 687689..687949 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF751_RS03250 (687978) 687978..688166 + 189 WP_000052076.1 hypothetical protein Toxin
IF751_RS03255 (688354) 688354..688923 + 570 WP_020977093.1 lipoprotein N-acylation protein LnsA -
IF751_RS03260 (689011) 689011..689295 + 285 WP_001004401.1 hypothetical protein -
IF751_RS03265 (689358) 689358..689576 + 219 WP_000005880.1 hypothetical protein -
IF751_RS03270 (690074) 690074..690274 - 201 WP_001059082.1 cold-shock protein -
IF751_RS03275 (690631) 690631..691317 - 687 WP_001641381.1 thermonuclease family protein -
IF751_RS03280 (691658) 691658..692130 - 473 Protein_652 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174982 WP_000052076.1 NZ_CP062407:687978-688166 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174982 NZ_CP081719:2907173-2907280 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174982 WP_001059690.1 NZ_CP062407:687689-687949 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174982 NZ_CP081719:c2907123-2907060 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References