174981

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2643552..2644081 Replicon chromosome
Accession NZ_CP062406
Organism Staphylococcus aureus strain NAS_NP_198

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IF753_RS12960 Protein ID WP_000621175.1
Coordinates 2643719..2644081 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IF753_RS12955 Protein ID WP_000948331.1
Coordinates 2643552..2643722 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF753_RS12925 (2638589) 2638589..2639149 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
IF753_RS12930 (2639357) 2639357..2639836 + 480 WP_001287087.1 hypothetical protein -
IF753_RS12935 (2639829) 2639829..2641412 + 1584 WP_001294626.1 PH domain-containing protein -
IF753_RS12940 (2641399) 2641399..2641890 + 492 WP_001205912.1 PH domain-containing protein -
IF753_RS12945 (2641894) 2641894..2642253 + 360 WP_000581197.1 holo-ACP synthase -
IF753_RS12950 (2642319) 2642319..2643467 + 1149 WP_001281154.1 alanine racemase -
IF753_RS12955 (2643552) 2643552..2643722 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IF753_RS12960 (2643719) 2643719..2644081 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IF753_RS12965 (2644431) 2644431..2645432 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
IF753_RS12970 (2645551) 2645551..2645877 + 327 WP_001052491.1 anti-sigma factor antagonist -
IF753_RS12975 (2645879) 2645879..2646358 + 480 WP_001190829.1 anti-sigma B factor RsbW -
IF753_RS12980 (2646333) 2646333..2647103 + 771 WP_001041111.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T174981 WP_000621175.1 NZ_CP062406:2643719-2644081 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T174981 NZ_CP081719:2906638-2906745 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT174981 WP_000948331.1 NZ_CP062406:2643552-2643722 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT174981 NZ_CP081719:c2906591-2906525 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References