Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2622308..2622822 Replicon chromosome
Accession NZ_CP062406
Organism Staphylococcus aureus strain NAS_NP_198

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF753_RS12860 Protein ID WP_000581792.1
Coordinates 2622613..2622822 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF753_RS12855 Protein ID WP_000138932.1
Coordinates 2622308..2622601 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF753_RS12835 (2617571) 2617571..2618212 + 642 WP_000483153.1 thiamine phosphate synthase -
IF753_RS12840 (2618298) 2618298..2619170 + 873 WP_000725802.1 membrane protein insertase YidC -
IF753_RS12845 (2619983) 2619983..2620630 - 648 WP_001187630.1 HD domain-containing protein -
IF753_RS12850 (2620658) 2620658..2622142 - 1485 WP_000571549.1 cardiolipin synthase -
IF753_RS12855 (2622308) 2622308..2622601 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF753_RS12860 (2622613) 2622613..2622822 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF753_RS12865 (2622950) 2622950..2623087 + 138 WP_000828354.1 Lmo0850 family protein -
IF753_RS12870 (2623351) 2623351..2624553 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF753_RS12875 (2624871) 2624871..2625941 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF753_RS12880 (2625956) 2625956..2627314 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174980 WP_000581792.1 NZ_CP062406:2622613-2622822 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174980 NZ_CP062406:2622613-2622822 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174980 WP_000138932.1 NZ_CP062406:2622308-2622601 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174980 NZ_CP062406:2622308-2622601 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References