Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1154296..1154773 | Replicon | chromosome |
| Accession | NZ_CP062406 | ||
| Organism | Staphylococcus aureus strain NAS_NP_198 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | IF753_RS05745 | Protein ID | WP_000052076.1 |
| Coordinates | 1154585..1154773 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | IF753_RS05740 | Protein ID | WP_001059690.1 |
| Coordinates | 1154296..1154556 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF753_RS05705 (1149689) | 1149689..1150405 | - | 717 | WP_000150011.1 | type I 3-dehydroquinate dehydratase | - |
| IF753_RS05710 (1150553) | 1150553..1150975 | + | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| IF753_RS05715 (1151374) | 1151374..1151868 | + | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| IF753_RS05720 (1152023) | 1152023..1152640 | + | 618 | WP_000255551.1 | LysE/ArgO family amino acid transporter | - |
| IF753_RS05725 (1152713) | 1152713..1153294 | - | 582 | WP_001140693.1 | histidine phosphatase family protein | - |
| IF753_RS05730 (1153519) | 1153519..1153755 | + | 237 | WP_000349581.1 | hypothetical protein | - |
| IF753_RS05735 (1153752) | 1153752..1153955 | - | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| IF753_RS05740 (1154296) | 1154296..1154556 | + | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| IF753_RS05745 (1154585) | 1154585..1154773 | + | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| IF753_RS05750 (1154961) | 1154961..1155530 | + | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
| IF753_RS05755 (1155618) | 1155618..1155902 | + | 285 | WP_001004399.1 | hypothetical protein | - |
| IF753_RS05760 (1155964) | 1155964..1156182 | + | 219 | WP_000005886.1 | hypothetical protein | - |
| IF753_RS05765 (1156674) | 1156674..1156874 | - | 201 | WP_001059082.1 | cold-shock protein | - |
| IF753_RS05770 (1157231) | 1157231..1157917 | - | 687 | WP_000141557.1 | thermonuclease family protein | - |
| IF753_RS05775 (1158258) | 1158258..1158779 | - | 522 | WP_000824482.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T174971 WP_000052076.1 NZ_CP062406:1154585-1154773 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T174971 NZ_CP081719:769370-769747 [Escherichia coli]
ATGCAAACCCAACCACTATCCTCAACTCAGGAGGCTACACCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACACTCAACGACACTCCGTTCGGCAACGATGGCGTGATTCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGATCTGGTACGAACCGACCGTCGCGGTTTT
AACGCAGAAACACAGTCGCCTCTTCTCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGACTGATGACCCGAAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGGGAGGTGCAGCCATGA
ATGCAAACCCAACCACTATCCTCAACTCAGGAGGCTACACCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACACTCAACGACACTCCGTTCGGCAACGATGGCGTGATTCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGATCTGGTACGAACCGACCGTCGCGGTTTT
AACGCAGAAACACAGTCGCCTCTTCTCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGACTGATGACCCGAAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGGGAGGTGCAGCCATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT174971 WP_001059690.1 NZ_CP062406:1154296-1154556 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT174971 NZ_CP081719:768960-769319 [Escherichia coli]
TTGTCGAATGAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTACAGGCGGGCAACCGTCTGCATTATCTCGCTGACCGGGCCAACATCACCGGACAGTTCAGCGACG
CTGATTTACGGTATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAAT
CCCTGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCATAA
TTGTCGAATGAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTACAGGCGGGCAACCGTCTGCATTATCTCGCTGACCGGGCCAACATCACCGGACAGTTCAGCGACG
CTGATTTACGGTATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAAT
CCCTGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |