Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1856152..1856666 Replicon chromosome
Accession NZ_CP062405
Organism Staphylococcus aureus strain NAS_NP_209

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag IF754_RS09435 Protein ID WP_000581791.1
Coordinates 1856152..1856361 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag IF754_RS09440 Protein ID WP_000138934.1
Coordinates 1856373..1856666 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF754_RS09415 (1852041) 1852041..1853111 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
IF754_RS09420 (1853429) 1853429..1854631 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF754_RS09425 (1854792) 1854792..1855475 - 684 Protein_1817 transposase -
IF754_RS09430 (1855887) 1855887..1856024 - 138 WP_000828354.1 Lmo0850 family protein -
IF754_RS09435 (1856152) 1856152..1856361 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
IF754_RS09440 (1856373) 1856373..1856666 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF754_RS09445 (1856832) 1856832..1858316 + 1485 WP_064139515.1 cardiolipin synthase -
IF754_RS09450 (1858344) 1858344..1858991 + 648 WP_001187612.1 HD domain-containing protein -
IF754_RS09455 (1859604) 1859604..1860476 - 873 WP_000725802.1 membrane protein insertase YidC -
IF754_RS09460 (1860562) 1860562..1861203 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T174959 WP_000581791.1 NZ_CP062405:c1856361-1856152 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174959 NZ_CP081713:c4298379-4298029 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT174959 WP_000138934.1 NZ_CP062405:c1856666-1856373 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174959 NZ_CP081713:c4298624-4298373 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References