174957

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1665986..1666762 Replicon chromosome
Accession NZ_CP062405
Organism Staphylococcus aureus strain NAS_NP_209

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag IF754_RS08345 Protein ID WP_000031108.1
Coordinates 1665986..1666138 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag IF754_RS08350 Protein ID WP_001251219.1
Coordinates 1666163..1666762 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF754_RS08330 (1662132) 1662132..1662953 + 822 WP_000669380.1 RluA family pseudouridine synthase -
IF754_RS08335 (1663409) 1663409..1664794 - 1386 WP_000116227.1 class II fumarate hydratase -
IF754_RS08340 (1664990) 1664990..1665385 - 396 WP_000901019.1 hypothetical protein -
IF754_RS08345 (1665986) 1665986..1666138 - 153 WP_000031108.1 SAS053 family protein Toxin
IF754_RS08350 (1666163) 1666163..1666762 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
IF754_RS08355 (1666921) 1666921..1667391 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
IF754_RS08360 (1667396) 1667396..1668523 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
IF754_RS08365 (1668674) 1668674..1669396 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
IF754_RS08370 (1669389) 1669389..1670846 - 1458 WP_000649898.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T174957 WP_000031108.1 NZ_CP062405:c1666138-1665986 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T174957 NZ_CP081713:c4114699-4114385 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT174957 WP_001251219.1 NZ_CP062405:c1666762-1666163 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT174957 NZ_CP081713:c4114935-4114702 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References