Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 606959..607436 Replicon chromosome
Accession NZ_CP062405
Organism Staphylococcus aureus strain NAS_NP_209

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF754_RS03195 Protein ID WP_000052076.1
Coordinates 606959..607147 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF754_RS03200 Protein ID WP_001059690.1
Coordinates 607176..607436 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF754_RS03165 (602912) 602912..603469 + 558 WP_000824491.1 hypothetical protein -
IF754_RS03170 (603810) 603810..604496 + 687 WP_001574556.1 thermonuclease family protein -
IF754_RS03175 (604853) 604853..605053 + 201 WP_001059082.1 cold-shock protein -
IF754_RS03180 (605550) 605550..605768 - 219 WP_000005879.1 hypothetical protein -
IF754_RS03185 (605830) 605830..606114 - 285 WP_001004401.1 hypothetical protein -
IF754_RS03190 (606202) 606202..606771 - 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
IF754_RS03195 (606959) 606959..607147 - 189 WP_000052076.1 hypothetical protein Toxin
IF754_RS03200 (607176) 607176..607436 - 261 WP_001059690.1 hypothetical protein Antitoxin
IF754_RS03205 (607777) 607777..607980 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF754_RS03210 (607977) 607977..608213 - 237 WP_000368687.1 hypothetical protein -
IF754_RS03215 (608438) 608438..609019 + 582 WP_001140696.1 histidine phosphatase family protein -
IF754_RS03220 (609092) 609092..609709 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
IF754_RS03225 (609865) 609865..610359 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF754_RS03230 (610758) 610758..611180 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
IF754_RS03235 (611328) 611328..612044 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174954 WP_000052076.1 NZ_CP062405:c607147-606959 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174954 NZ_CP081713:2907165-2907272 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174954 WP_001059690.1 NZ_CP062405:c607436-607176 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174954 NZ_CP081713:c2907115-2907052 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References