174942

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1815233..1815747 Replicon chromosome
Accession NZ_CP062404
Organism Staphylococcus aureus strain NAS_NP_229

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag IF757_RS09095 Protein ID WP_000581791.1
Coordinates 1815233..1815442 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag IF757_RS09100 Protein ID WP_000138934.1
Coordinates 1815454..1815747 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF757_RS09075 (1811122) 1811122..1812192 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
IF757_RS09080 (1812510) 1812510..1813712 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF757_RS09085 (1813873) 1813873..1814556 - 684 Protein_1750 transposase -
IF757_RS09090 (1814968) 1814968..1815105 - 138 WP_000828354.1 Lmo0850 family protein -
IF757_RS09095 (1815233) 1815233..1815442 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
IF757_RS09100 (1815454) 1815454..1815747 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF757_RS09105 (1815913) 1815913..1817397 + 1485 WP_064139515.1 cardiolipin synthase -
IF757_RS09110 (1817425) 1817425..1818072 + 648 WP_001187612.1 HD domain-containing protein -
IF757_RS09115 (1818229) 1818229..1818528 + 300 WP_001793952.1 hypothetical protein -
IF757_RS09120 (1818685) 1818685..1819557 - 873 WP_000725802.1 membrane protein insertase YidC -
IF757_RS09125 (1819643) 1819643..1820284 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T174942 WP_000581791.1 NZ_CP062404:c1815442-1815233 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174942 NZ_CP081713:704538-704852 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT174942 WP_000138934.1 NZ_CP062404:c1815747-1815454 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174942 NZ_CP081713:704849-705265 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCAAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References