Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 566040..566517 Replicon chromosome
Accession NZ_CP062404
Organism Staphylococcus aureus strain NAS_NP_229

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF757_RS02850 Protein ID WP_000052076.1
Coordinates 566040..566228 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF757_RS02855 Protein ID WP_001059690.1
Coordinates 566257..566517 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF757_RS02820 (561993) 561993..562550 + 558 WP_000824491.1 hypothetical protein -
IF757_RS02825 (562891) 562891..563577 + 687 WP_001574556.1 thermonuclease family protein -
IF757_RS02830 (563934) 563934..564134 + 201 WP_001059082.1 cold-shock protein -
IF757_RS02835 (564631) 564631..564849 - 219 WP_000005879.1 hypothetical protein -
IF757_RS02840 (564911) 564911..565195 - 285 WP_001004401.1 hypothetical protein -
IF757_RS02845 (565283) 565283..565852 - 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
IF757_RS02850 (566040) 566040..566228 - 189 WP_000052076.1 hypothetical protein Toxin
IF757_RS02855 (566257) 566257..566517 - 261 WP_001059690.1 hypothetical protein Antitoxin
IF757_RS02860 (566858) 566858..567061 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF757_RS02865 (567058) 567058..567294 - 237 WP_000368687.1 hypothetical protein -
IF757_RS02870 (567519) 567519..568100 + 582 WP_001140696.1 histidine phosphatase family protein -
IF757_RS02875 (568173) 568173..568790 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
IF757_RS02880 (568946) 568946..569440 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF757_RS02885 (569839) 569839..570261 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
IF757_RS02890 (570409) 570409..571125 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174937 WP_000052076.1 NZ_CP062404:c566228-566040 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174937 NZ_CP081711:c4235791-4235618 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174937 WP_001059690.1 NZ_CP062404:c566517-566257 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174937 NZ_CP081711:c4236115-4235819 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References