Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2659212..2659741 Replicon chromosome
Accession NZ_CP062403
Organism Staphylococcus aureus strain NAS_OP_052

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IF765_RS13090 Protein ID WP_000621175.1
Coordinates 2659379..2659741 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IF765_RS13085 Protein ID WP_000948331.1
Coordinates 2659212..2659382 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF765_RS13055 (2654248) 2654248..2654808 + 561 WP_001092409.1 K(+)-transporting ATPase subunit C -
IF765_RS13060 (2655017) 2655017..2655496 + 480 WP_001287079.1 hypothetical protein -
IF765_RS13065 (2655489) 2655489..2657072 + 1584 WP_001294620.1 PH domain-containing protein -
IF765_RS13070 (2657059) 2657059..2657550 + 492 WP_001205912.1 PH domain-containing protein -
IF765_RS13075 (2657554) 2657554..2657913 + 360 WP_000581197.1 holo-ACP synthase -
IF765_RS13080 (2657979) 2657979..2659127 + 1149 WP_001281154.1 alanine racemase -
IF765_RS13085 (2659212) 2659212..2659382 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IF765_RS13090 (2659379) 2659379..2659741 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IF765_RS13095 (2660091) 2660091..2661092 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
IF765_RS13100 (2661211) 2661211..2661537 + 327 WP_001052491.1 anti-sigma factor antagonist -
IF765_RS13105 (2661539) 2661539..2662018 + 480 WP_001190829.1 anti-sigma B factor RsbW -
IF765_RS13110 (2661993) 2661993..2662763 + 771 WP_001041103.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T174933 WP_000621175.1 NZ_CP062403:2659379-2659741 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T174933 NZ_CP081711:2663951-2664058 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTTGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT174933 WP_000948331.1 NZ_CP062403:2659212-2659382 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT174933 NZ_CP081711:c2663904-2663838 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References