Detailed information of TA system TA174923

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1157247..1157724
• Replicon: chromosome
• Accession: NZ_CP062403
• Organism: Staphylococcus aureus strain NAS_OP_052

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF765_RS05755
• Protein ID: WP_000052076.1
• Coordinates: 1157536..1157724 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF765_RS05750
• Protein ID: WP_001059690.1
• Coordinates: 1157247..1157507 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF765_RS05715 (1152640)	1152640..1153356	-	717	WP_000150019.1	type I 3-dehydroquinate dehydratase	-
IF765_RS05720 (1153504)	1153504..1153926	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF765_RS05725 (1154325)	1154325..1154819	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF765_RS05730 (1154974)	1154974..1155591	+	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
IF765_RS05735 (1155664)	1155664..1156245	-	582	WP_001140697.1	histidine phosphatase family protein	-
IF765_RS05740 (1156470)	1156470..1156706	+	237	WP_000368687.1	hypothetical protein	-
IF765_RS05745 (1156703)	1156703..1156906	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF765_RS05750 (1157247)	1157247..1157507	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF765_RS05755 (1157536)	1157536..1157724	+	189	WP_000052076.1	hypothetical protein	Toxin
IF765_RS05760 (1157912)	1157912..1158481	+	570	WP_001106652.1	lipoprotein N-acylation protein LnsA	-
IF765_RS05765 (1158569)	1158569..1158853	+	285	WP_001004394.1	hypothetical protein	-
IF765_RS05770 (1158915)	1158915..1159140	+	226	Protein_1112	hypothetical protein	-
IF765_RS05775 (1159635)	1159635..1159835	-	201	WP_001059082.1	cold-shock protein	-
IF765_RS05780 (1160192)	1160192..1160878	-	687	WP_001566557.1	thermonuclease family protein	-
IF765_RS05785 (1161219)	1161219..1161689	-	471	WP_000824472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T174923 WP_000052076.1 NZ_CP062403:1157536-1157724 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T174923 NZ_CP081711:741416-741712 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT174923 WP_001059690.1 NZ_CP062403:1157247-1157507 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT174923 NZ_CP081711:741714-742109 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56