Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 122521..123297 Replicon chromosome
Accession NZ_CP062403
Organism Staphylococcus aureus strain NAS_OP_052

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag IF765_RS00785 Protein ID WP_000031108.1
Coordinates 123145..123297 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag IF765_RS00780 Protein ID WP_001251224.1
Coordinates 122521..123120 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF765_RS00760 (118437) 118437..119894 + 1458 WP_000649908.1 ABC transporter permease subunit -
IF765_RS00765 (119887) 119887..120609 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
IF765_RS00770 (120760) 120760..121887 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
IF765_RS00775 (121892) 121892..122362 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
IF765_RS00780 (122521) 122521..123120 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
IF765_RS00785 (123145) 123145..123297 + 153 WP_000031108.1 SAS053 family protein Toxin
IF765_RS00790 (123845) 123845..124240 + 396 WP_000901023.1 hypothetical protein -
IF765_RS00795 (124436) 124436..125821 + 1386 WP_000116229.1 class II fumarate hydratase -
IF765_RS00800 (126273) 126273..127094 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T174920 WP_000031108.1 NZ_CP062403:123145-123297 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T174920 NZ_CP081711:214102-214209 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT174920 WP_001251224.1 NZ_CP062403:122521-123120 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT174920 NZ_CP081711:c214054-213988 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References