Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2049737..2050251 Replicon chromosome
Accession NZ_CP062402
Organism Staphylococcus aureus strain NAS_OP_056

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF766_RS09985 Protein ID WP_000581792.1
Coordinates 2049737..2049946 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF766_RS09990 Protein ID WP_000138932.1
Coordinates 2049958..2050251 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF766_RS09965 (IF766_09930) 2045245..2046603 - 1359 WP_000611470.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
IF766_RS09970 (IF766_09935) 2046618..2047688 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF766_RS09975 (IF766_09940) 2048006..2049208 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF766_RS09980 (IF766_09945) 2049472..2049609 - 138 WP_000828354.1 Lmo0850 family protein -
IF766_RS09985 (IF766_09950) 2049737..2049946 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF766_RS09990 (IF766_09955) 2049958..2050251 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF766_RS09995 (IF766_09960) 2050417..2051901 + 1485 WP_000571549.1 cardiolipin synthase -
IF766_RS10000 (IF766_09965) 2051929..2052576 + 648 WP_001187630.1 HD domain-containing protein -
IF766_RS10005 (IF766_09970) 2053048..2053920 - 873 WP_000725802.1 membrane protein insertase YidC -
IF766_RS10010 (IF766_09975) 2054006..2054647 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174911 WP_000581792.1 NZ_CP062402:c2049946-2049737 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174911 NZ_CP081706:c2451664-2451182 [Escherichia coli]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174911 WP_000138932.1 NZ_CP062402:c2050251-2049958 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174911 NZ_CP081706:c2451918-2451652 [Escherichia coli]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References