Detailed information of TA system TA174909

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1866987..1867763
• Replicon: chromosome
• Accession: NZ_CP062402
• Organism: Staphylococcus aureus strain NAS_OP_056

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: IF766_RS08955
• Protein ID: WP_000031108.1
• Coordinates: 1866987..1867139 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: IF766_RS08960
• Protein ID: WP_001251229.1
• Coordinates: 1867164..1867763 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF766_RS08940 (IF766_08915)	1862903..1863724	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
IF766_RS08945 (IF766_08920)	1864177..1865562	-	1386	WP_000116231.1	class II fumarate hydratase	-
IF766_RS08950 (IF766_08925)	1865758..1866153	-	396	WP_000901023.1	hypothetical protein	-
IF766_RS08955 (IF766_08930)	1866987..1867139	-	153	WP_000031108.1	SAS053 family protein	Toxin
IF766_RS08960 (IF766_08935)	1867164..1867763	-	600	WP_001251229.1	glucosamine-6-phosphate isomerase	Antitoxin
IF766_RS08965 (IF766_08940)	1867921..1868391	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
IF766_RS08970 (IF766_08945)	1868396..1869523	-	1128	WP_029160281.1	tRNA epoxyqueuosine(34) reductase QueG	-
IF766_RS08975 (IF766_08950)	1869674..1870396	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
IF766_RS08980 (IF766_08955)	1870389..1871846	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T174909 WP_000031108.1 NZ_CP062402:c1867139-1866987 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T174909 NZ_CP081706:2069707-2069810 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22329.45 Da
• Isoelectric Point: 5.1445

>AT174909 WP_001251229.1 NZ_CP062402:c1867763-1867164 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEGLGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT174909 NZ_CP081706:c2069848-2069577 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: X5E2E6