Detailed information of TA system TA174906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 827124..827601
• Replicon: chromosome
• Accession: NZ_CP062402
• Organism: Staphylococcus aureus strain NAS_OP_056

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF766_RS03960
• Protein ID: WP_000052076.1
• Coordinates: 827124..827312 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF766_RS03965
• Protein ID: WP_001059690.1
• Coordinates: 827341..827601 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF766_RS03930 (IF766_03905)	823114..823635	+	522	WP_000824484.1	hypothetical protein	-
IF766_RS03935 (IF766_03910)	823976..824662	+	687	WP_001792695.1	thermonuclease family protein	-
IF766_RS03940 (IF766_03915)	825019..825219	+	201	WP_001059082.1	cold-shock protein	-
IF766_RS03945 (IF766_03920)	825715..825933	-	219	WP_000005886.1	hypothetical protein	-
IF766_RS03950 (IF766_03925)	825995..826279	-	285	WP_001004395.1	hypothetical protein	-
IF766_RS03955 (IF766_03930)	826367..826936	-	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
IF766_RS03960 (IF766_03935)	827124..827312	-	189	WP_000052076.1	hypothetical protein	Toxin
IF766_RS03965 (IF766_03940)	827341..827601	-	261	WP_001059690.1	hypothetical protein	Antitoxin
IF766_RS03970 (IF766_03945)	827942..828145	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF766_RS03975 (IF766_03950)	828142..828378	-	237	WP_000368687.1	hypothetical protein	-
IF766_RS03980 (IF766_03955)	828603..829184	+	582	WP_001140693.1	histidine phosphatase family protein	-
IF766_RS03985 (IF766_03960)	829257..829874	-	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
IF766_RS03990 (IF766_03965)	830029..830523	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF766_RS03995 (IF766_03970)	830922..831344	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF766_RS04000 (IF766_03975)	831492..832208	+	717	WP_000150012.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T174906 WP_000052076.1 NZ_CP062402:c827312-827124 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T174906 NZ_CP081706:950193-950600 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT174906 WP_001059690.1 NZ_CP062402:c827601-827341 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT174906 NZ_CP081706:949946-950212 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56