Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 382856..383385 Replicon chromosome
Accession NZ_CP062402
Organism Staphylococcus aureus strain NAS_OP_056

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag IF766_RS01765 Protein ID WP_001103933.1
Coordinates 383068..383385 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A2X2M557
Locus tag IF766_RS01760 Protein ID WP_001058488.1
Coordinates 382856..383065 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF766_RS01730 (IF766_01715) 378577..380118 + 1542 WP_000424963.1 glutamine-hydrolyzing GMP synthase -
IF766_RS01735 (IF766_01720) 380212..381348 - 1137 WP_000592973.1 site-specific integrase -
IF766_RS01740 (IF766_01725) 381444..382121 - 678 WP_239858572.1 helix-turn-helix transcriptional regulator -
IF766_RS01745 (IF766_01730) 382211..382408 + 198 WP_000466891.1 helix-turn-helix transcriptional regulator -
IF766_RS01750 (IF766_01735) 382410..382670 + 261 WP_001147662.1 hypothetical protein -
IF766_RS01755 (IF766_01740) 382717..382863 + 147 WP_000780975.1 hypothetical protein -
IF766_RS01760 (IF766_01745) 382856..383065 + 210 WP_001058488.1 hypothetical protein Antitoxin
IF766_RS01765 (IF766_01750) 383068..383385 + 318 WP_001103933.1 DUF1474 family protein Toxin
IF766_RS01770 (IF766_01755) 383452..384321 + 870 WP_001002701.1 primase alpha helix C-terminal domain-containing protein -
IF766_RS01775 (IF766_01760) 384335..386044 + 1710 WP_000447454.1 DUF927 domain-containing protein -
IF766_RS01780 (IF766_01765) 386375..386755 + 381 WP_000356927.1 hypothetical protein -
IF766_RS01785 (IF766_01770) 386752..387393 + 642 WP_064140196.1 pathogenicity island protein -
IF766_RS01790 (IF766_01775) 387929..388270 + 342 WP_001190614.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sec / sell 375780..400955 25175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T174905 WP_001103933.1 NZ_CP062402:383068-383385 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T174905 NZ_CP081706:870348-871661 [Escherichia coli]
ATGAAAATGCAGACGCTAACAGTGGCGATGAATGGTGAGGTCGTAGGAACACTGTACCGAGATAACAAAGGGGCCATGTC
ATTTCAGTATGCCCCGGAGTGGATCTCGGAACCAGGTTCACGCGCCATTTCCATGTCACTGCCTTTGGGTCATGGCAGGA
TCACAGGAAGTGAAGTCTTCAATTTCTTTAGCAACCTCCTACCCGACTCAGAGGCAATTATTGCCAGGATGCAGGCTAGG
TTCAGAGTTGAGACAACACATCCATTTGATTTGCTGGCGAGTGTTGGCCGGGATTGTGTTGGAGCTATCCAGCTCTATTC
CCCCGATGCGGACATCCCAACTGTAATGGAGACGCTTGCAGAGCCTCTGGATGAAGCTCAGATTGAGCAACTGCTTGAAG
GCTACCAGGAAGCGCCCCTTGGGATGGCAGAGGATGCTGATTTTCGGATCTCGATTGCCGGAGCCCAAGAGAAAACTGCA
CTGCTTTGGTATCAGGACCGCTGGCAACGCCCCCTGGGCAGCACCCCAACAAGCCATATTTTTAAGCTACCCATTGGTAA
GATTGTTCAAAATAACATCGATCTCAGTGAGAGTTGTGAGAATGAATGGCTCTGTTTGCGCATTGCAAAGGCCTTCGGTT
TTGACGTCGCCAATGCGGACCTAGCAACGTTCGGCAAGAAGAAGGTGCTTGTCGTTCAGCGTTTTGACCGGCGCTGGTCT
AAATCCGGCGAATGGCTTCTACGATTGCCCCAAGAAGACTTCTGCCAAGCTCTTGGGATCGCTCCTGCGCTCAAATACGA
GTCACATGGAGGGCCAGGTATTGCTGACGCAATGAAGTTGTTGTTGGGGTCCAGACTTGCGGCTAAGGATAGAGAGCAAT
TTTTCAAGTCGCAGATCCTATTCTGGATGTTGGCCGCGATTGATGGGCACGGGAAGAACTTCTCCATCTTCATTGAGCCT
GCATCGTCATTTAGGATGACCCCCCTCTACGATGTCATGTCTGCTTTTCCTATCTTCAAAAGCGGGGGAATTGCTGCTCA
AAAGGCAAAGATGGGGATGGCGCTCCAAGGCAAAAACCGCCAATACCATTTTGCGATGATCCAGCCTCGTCATTTTATCA
GTACCGCCGCCCATGTCGGGTTCCCACAAGATACCGCCGCTCAACTTATGTTCGACATGGCTACCAAGACAGAGGAGGTG
GTTGCCACAGTAGCGGCTGAGCTGCCAGCCGGTTTCCCAGAGCACATCAGTAGCGCCATCTTCGAGGGGCTGTCCAGCCA
GGCGGCTAAGATCTTGAAGGGAGTAGCCAAATGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8287.31 Da        Isoelectric Point: 4.2820

>AT174905 WP_001058488.1 NZ_CP062402:382856-383065 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT174905 NZ_CP081706:870093-870344 [Escherichia coli]
ATGAAAGTGACATCTCCATCCTTGCTTGCGGCTGCGGTGCGTGACCAGCGCAAGCTCAGCAAACTAACGCAGTCAGAGGC
GGCGAAACAGGTCGGAATCAAGCAGACGACCGTCTCTGATTTTGAACTACGGCCAGAATCTACCAAGCTGGAGACGCTAT
TCAAGCTCCTTTCTGCACTGGATCTGGAGCTTCATGTCGTGAAGCGGGGTTCAACATTGGACGATAGTAAAGTCTGGGAT
AGGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2M557

References