Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2695346..2695860 Replicon chromosome
Accession NZ_CP062401
Organism Staphylococcus aureus strain NAS_OP_098

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF770_RS13395 Protein ID WP_000581792.1
Coordinates 2695651..2695860 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF770_RS13390 Protein ID WP_000138932.1
Coordinates 2695346..2695639 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF770_RS13370 (2690609) 2690609..2691250 + 642 WP_000483153.1 thiamine phosphate synthase -
IF770_RS13375 (2691336) 2691336..2692208 + 873 WP_000725802.1 membrane protein insertase YidC -
IF770_RS13380 (2693021) 2693021..2693668 - 648 WP_001187630.1 HD domain-containing protein -
IF770_RS13385 (2693696) 2693696..2695180 - 1485 WP_000571549.1 cardiolipin synthase -
IF770_RS13390 (2695346) 2695346..2695639 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF770_RS13395 (2695651) 2695651..2695860 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF770_RS13400 (2695988) 2695988..2696125 + 138 WP_000828354.1 Lmo0850 family protein -
IF770_RS13405 (2696389) 2696389..2697591 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF770_RS13410 (2697909) 2697909..2698979 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF770_RS13415 (2698994) 2698994..2700352 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174902 WP_000581792.1 NZ_CP062401:2695651-2695860 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174902 NZ_CP081706:c598853-598389 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174902 WP_000138932.1 NZ_CP062401:2695346-2695639 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174902 NZ_CP081706:c599188-598853 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References