Detailed information of TA system TA174893

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1201504..1201981
• Replicon: chromosome
• Accession: NZ_CP062401
• Organism: Staphylococcus aureus strain NAS_OP_098

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF770_RS06090
• Protein ID: WP_000052076.1
• Coordinates: 1201793..1201981 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF770_RS06085
• Protein ID: WP_001059690.1
• Coordinates: 1201504..1201764 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF770_RS06050 (1196897)	1196897..1197613	-	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-
IF770_RS06055 (1197761)	1197761..1198183	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF770_RS06060 (1198582)	1198582..1199076	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF770_RS06065 (1199231)	1199231..1199848	+	618	WP_000255551.1	LysE/ArgO family amino acid transporter	-
IF770_RS06070 (1199921)	1199921..1200502	-	582	WP_001140693.1	histidine phosphatase family protein	-
IF770_RS06075 (1200727)	1200727..1200963	+	237	WP_000349581.1	hypothetical protein	-
IF770_RS06080 (1200960)	1200960..1201163	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF770_RS06085 (1201504)	1201504..1201764	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF770_RS06090 (1201793)	1201793..1201981	+	189	WP_000052076.1	hypothetical protein	Toxin
IF770_RS06095 (1202169)	1202169..1202738	+	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
IF770_RS06100 (1202826)	1202826..1203110	+	285	WP_001004399.1	hypothetical protein	-
IF770_RS06105 (1203172)	1203172..1203390	+	219	WP_000005886.1	hypothetical protein	-
IF770_RS06110 (1203882)	1203882..1204082	-	201	WP_001059082.1	cold-shock protein	-
IF770_RS06115 (1204439)	1204439..1205125	-	687	WP_000141557.1	thermonuclease family protein	-
IF770_RS06120 (1205466)	1205466..1205987	-	522	WP_049311898.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	1197761..1235119	37358

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (6-104)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T174893 WP_000052076.1 NZ_CP062401:1201793-1201981 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T174893 NZ_CP081701:3764004-3764345 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT174893 WP_001059690.1 NZ_CP062401:1201504-1201764 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT174893 NZ_CP081701:3763666-3763983 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56